Evidence map›Paper›PMID 35461900›Full record

ReviewCellular signalling2022

Exosomal mediated signal transduction through artificial microRNA (amiRNA): A potential target for inhibition of SARS-CoV-2.

Chithravel Vadivalagan, Anushka Shitut, Siva Kamalakannan, Ruei-Ming Chen, Ángel Serrano-Aroca, Vijay Mishra, Alaa A A Aljabali, Sachin Kumar Singh, Dinesh Kumar Chellappan, Gaurav Gupta and 4 more

Open access · hybridAbstract readReview
In one paragraph

Review in Cellular signalling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Exosome and virus infection.Frontiers in immunology · 2023
    Review
  5. Elevated Expression ofJournal of personalized medicine · 2022
    Article
  6. Frontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 13 institutions in 9 countries.

Chithravel VadivalaganGraduate Institute of Medical Sciences, College of medicine, Taipei Medical University, Taipei 110, Taiwan; Department of Biochemistry, AKFA Medical School, AKFA University, Tashkent, Uzbekistan. Electronic address: marinedrug.9@gmail.com.
Anushka ShitutDepartment of Life Sciences, Christ University, Bhavani, Nagar, Bangalor, Karnataka 560029, India. Electronic address: anushka.shitut@science.christuniversity.in.
Siva KamalakannanNational Center for Disease Control, Ministry of Health and Family Welfare, Government of India, New Delhi 110054, India.
Ruei-Ming ChenGraduate Institute of Medical Sciences, College of medicine, Taipei Medical University, Taipei 110, Taiwan.
Ángel Serrano-ArocaBiomaterials and Bioengineering Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain.
Vijay MishraSchool of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T Road, Phagwara, Punjab, India.
Alaa A A AljabaliDepartment of Pharmaceutics and Pharmaceutical Technology, Yarmouk University-Faculty of Pharmacy, Irbid 21163, Jordan.
Sachin Kumar SinghSchool of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T Road, Phagwara, Punjab, India; Faculty of Health, Australian Research Centre in Complementary & Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Dinesh Kumar ChellappanSchool of Pharmacy, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia.
Gaurav GuptaSchool of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun 248007, India.
Kamal DuaSchool of Pharmacy, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007, Australia.
Mohamed El-TananiPharmacological and Diagnostic Research Centre, Al-Ahliyya Amman University, Faculty of Pharmacy, Amman, Jordan.
Murtaza M TambuwalaSchool of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine, United Kingdom. Electronic address: m.tambuwala@ulster.ac.uk.
Anand KrishnanDepartment of Chemical Pathology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein 9300, South Africa; Department of Chemical Pathology, School of Pathology, National Health Laboratory Services, Bloemfontein, South Africa. Electronic address: organicanand@gmail.com.
Lovely Professional University · INAl-Ahliyya Amman University · JOCentral Asian University · UZChrist University · INGovernment of India · INGyan Vihar University · INInternational Medical University · MYTaipei Medical University · TWUniversity of Technology Sydney · AUUniversity of the Free State · ZAUniversity of Ulster · GBValencia Catholic University Saint Vincent Martyr · ESYarmouk University · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosome trans-membrane signals provide cellular communication between the cells through transport and/or receiving the signal by molecule, change the functional metabolism, and stimulate and/or inhibit receptor signal complexes. COVID19 genetic transformations are varied in different geographic positions, and single nucleotide polymorphic lineages were reported in the second waves due to the fast mutational rate and adaptation. Several vaccines were developed and in treatment practice, but effective control has yet to reach in cent presence. It was initially a narrow immune-modulating protein target. Controlling these diverse viral strains may inhibit their transuding mechanisms primarily to target RNA genes responsible for COVID19 transcription. Exosomal miRNAs are the main sources of transmembrane signals, and trans-located miRNAs can directly target COVID19 mRNA transcription. This review discussed targeted viral transcription by delivering the artificial miRNA (amiRNA) mediated exosomes in the infected cells and significant resources of exosome and their efficacy.

Indexed as

COVID-19ExosomesMicroRNAsHumansSARS-CoV-2Signal TransductionMicroRNAsArtificial miRNACOVID19 mutantExosomesInhibitionTranscription

Identifiers

PMID35461900
PMCPMC9022400
OpenAlexW4224289906

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.