Evidence map›Paper›PMID 35462792›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2022

Quantification of Unmethylated Insulin DNA Using Methylation Sensitive Restriction Enzyme Digital Polymerase Chain Reaction.

Fenna E M van de Leemkolk, Rogier J Nell, Mieke Versluis, Eelco J P de Koning, Volkert A L Huurman, Ian P J Alwayn, Rutger J Ploeg, Pieter A van der Velden, Marten A Engelse

Open access · goldAbstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Fenna E M van de LeemkolkLUMC Transplant Center, Leiden University Medical Center, Leiden, Netherlands.
Rogier J NellDepartment of Ophthalmology, Leiden University Medical Center, Leiden, Netherlands.
Mieke VersluisDepartment of Ophthalmology, Leiden University Medical Center, Leiden, Netherlands.
Eelco J P de KoningLUMC Transplant Center, Leiden University Medical Center, Leiden, Netherlands.
Volkert A L HuurmanLUMC Transplant Center, Leiden University Medical Center, Leiden, Netherlands.
Ian P J AlwaynLUMC Transplant Center, Leiden University Medical Center, Leiden, Netherlands.
Rutger J PloegLUMC Transplant Center, Leiden University Medical Center, Leiden, Netherlands.
Pieter A van der VeldenDepartment of Ophthalmology, Leiden University Medical Center, Leiden, Netherlands.
Marten A EngelseLUMC Transplant Center, Leiden University Medical Center, Leiden, Netherlands.
Leiden University Medical Center · NLNetherlands School of Public Administration · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Assessment of specific β-cell death can be used to determine the quality and viability of pancreatic islets prior to transplantation and hence predict the suitability of the pancreas for isolation. Recently, several groups have demonstrated that unmethylated insulin (

Indexed as

Insulin-Secreting CellsIslets of LangerhansDNADNA MethylationHumansInsulinPolymerase Chain ReactionDNAInsulinbiomarkerdigital PCRisletsmethylation sensitive restriction enzymetransplantationunmethylated insulin DNAβ-cell

Identifiers

PMID35462792
PMCPMC9022224
OpenAlexW4225511322

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.