Evidence map›Paper›PMID 35466449›Full record

Trial reportJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2022

Calcium Citrate Versus Calcium Carbonate in the Management of Chronic Hypoparathyroidism: A Randomized, Double-Blind, Crossover Clinical Trial.

Anda Mihaela Naciu, Gaia Tabacco, John P Bilezikian, Assunta Santonati, Daniela Bosco, Giosuè Giordano Incognito, Gianluigi Gaspa, Silvia Manfrini, Alberto Falchetti, Pierpaolo Trimboli and 6 more

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Citrate-based dietary alkali supplements available in Germany: an overview.Journal of pharmaceutical health care and sciences · 2024
    Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 3 countries.

Anda Mihaela Naciu *Unit of Metabolic Bone and Thyroid Disorders, Fondazione Policlinico Universitario Campus Bio-Medico, Rome.
Gaia Tabacco *Unit of Metabolic Bone and Thyroid Disorders, Fondazione Policlinico Universitario Campus Bio-Medico, Rome.
John P BilezikianDepartment of Medicine, Division of Endocrinology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.
Assunta SantonatiDepartment of Endocrinology, San Giovanni Addolorata Hospital, Rome, Italy.
Daniela BoscoDepartment of Endocrinology, San Giovanni Addolorata Hospital, Rome, Italy.
Giosuè Giordano IncognitoUnit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome.ORCID 0000-0002-1818-0105
Gianluigi GaspaDepartment of Food Science and Nutrition, University Campus Bio-Medico, Rome, Italy.
Silvia ManfriniUnit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome.
Alberto FalchettiDepartment of Endocrine and Metabolic Diseases, IRCCS, Istituto Auxologico Italiano, Milan, Italy.
Pierpaolo TrimboliClinic for Endocrinology and Diabetology, Lugano Regional Hospital, Ente Ospedaliero Cantonale, Lugano, Switzerland.
Gherardo MazziottiDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.
Nicola NapoliUnit of Metabolic Bone and Thyroid Disorders, Fondazione Policlinico Universitario Campus Bio-Medico, Rome.ORCID 0000-0002-3091-8205
Gianfranco SansonClinical Department of Medical, Surgical, and Health Sciences, University of Trieste, Trieste, Italy.
Roberto CesareoUOS Malattie Metaboliche, Santa Maria Goretti Hospital, Latina, Italy.
Fabio Vescini *Endocrinology and Metabolism Unit, University-Hospital S. M. Misericordia of Udine, Udine, Italy.
Andrea Palermo *Unit of Metabolic Bone and Thyroid Disorders, Fondazione Policlinico Universitario Campus Bio-Medico, Rome.ORCID 0000-0002-1143-4926
Università Campus Bio-Medico · ITAzienda Ospedaliera San Giovanni Addolorata · ITColumbia University · USHumanitas University · ITIRCCS Istituto Auxologico Italiano · ITOspedale regionale di Lugano · CHOspedale Santa Maria Goretti · ITUniversity of Trieste · ITUniversity of Udine · IT

Funding

Campus Bio-Medico University
6 · The paper itself

Abstract

In hypoparathyroidism (HypoPT), calcium supplementation is virtually always required, although the disease is likely to be associated with an increased risk of nephrolithiasis. The use of calcium citrate (Ca-Cit) theoretically could have a positive impact on the nephrolithiasis risk because citrate salts are used to reduce this risk. Our objective was to evaluate the potential therapeutic advantage of Ca-Cit in comparison with calcium carbonate (CaCO

Indexed as

HypoparathyroidismNephrolithiasisAdultCalciumCalcium CarbonateCalcium CitrateCalcium, DietaryCalcium OxalateConstipationCross-Over StudiesHumansOxalatesQuality of LifeCalciumCalcium CarbonateCalcium CitrateCalcium, DietaryCalcium OxalateOxalatesCALCIUM CARBONATECALCIUM CITRATEHYPOPARATHYROIDISMNEPHROLITHIASISPTH

Identifiers

PMID35466449
PMCPMC9542059
OpenAlexW4224311553

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.