ReviewJournal of enzyme inhibition and medicinal chemistry2022
Paving the way towards effective plant-based inhibitors of hyaluronidase and tyrosinase: a critical review on a structure-activity relationship.
Review in Journal of enzyme inhibition and medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 44 citations in OpenAlex.
- Comparative Phytochemical and Biological Evaluation of Four Thymus Species From Türkiye for Dermocosmetic Applications.Chemistry & biodiversity · 2026Article
- Solvent Polarity Shapes Antioxidant Capacity, Preliminary Hyaluronidase Inhibition, and Chemical Profile ofMolecules (Basel, Switzerland) · 2026Article
- Red Clover Isoflavones as Effective Longevity Agents for Anti-Aging and Regenerative Skin Applications.Plants (Basel, Switzerland) · 2026Article
- Unlocking the Functional Value of European-OriginatedMolecules (Basel, Switzerland) · 2026Article
- Comparative inhibitory effects of phillyrin and phillygenin on elastase: mechanisms and therapeutic potential.Frontiers in nutrition · 2026Article
- Green ultrasound‑assisted deep eutectic solvent extraction of flavonoid enzyme inhibitors fromJournal of enzyme inhibition and medicinal chemistry · 2025Article
- Quorum quenching: A key biological activity of marine actinobacteria extracts for acne vulgaris control.Biotechnology reports (Amsterdam, Netherlands) · 2025Article
- Hyaluronidases as Targets for the Treatment of Neurological Diseases.Proteoglycan research · 2025Article
- Article
- Effect of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one-containing lactic acid bacterial beverages on skin moisture: a randomized, double-blind, placebo-controlled, parallel study.Journal of clinical biochemistry and nutrition · 2025Article
- Sources and Applications of Tyrosinase in Life Sciences.Current pharmaceutical biotechnology · 2025Review
- Chemical profile ofFrontiers in chemistry · 2025Article
- Production ofJournal of fungi (Basel, Switzerland) · 2024Article
- Distinct chemical structures inhibit the CEMIP hyaluronidase and promote oligodendrocyte progenitor cell maturation.The Journal of biological chemistry · 2024Article
- Variation in the Phenolic Profile and Antioxidant, Antihyperglycemic, and Anti-Inflammatory Activity in Leaves ofMolecules (Basel, Switzerland) · 2024Article
- Article
- Ethyl Acetate Fraction fromMolecules (Basel, Switzerland) · 2024Article
- Article
- Total Synthesis and Bioactivity Profile of (+)-Ieodomycins A and B and their Stereoisomers.ACS omega · 2024Article
- Microbes, macrophages, and melanin: a unifying theory of disease as exemplified by cancer.Frontiers in immunology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human has used plants to treat many civilisation diseases for thousands of years. Examples include reserpine (hypertension therapy), digoxin (myocardial diseases), vinblastine and vincristine (cancers), and opioids (palliative treatment). Plants are a rich source of natural metabolites with multiple biological activities, and the use of modern approaches and tools allowed finally for more effective bioprospecting. The new phytochemicals are hyaluronidase (Hyal) inhibitors, which could serve as anti-cancer drugs, male contraceptives, and an antidote against venoms. In turn, tyrosinase inhibitors can be used in cosmetics/pharmaceuticals as whitening agents and to treat skin pigmentation disorders. However, the activity of these inhibitors is
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.