Evidence map›Paper›PMID 35476445›Full record

ArticleScience advances2022

Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition.

Nadine M Shaban, Rui Yan, Ke Shi, Sofia N Moraes, Adam Z Cheng, Michael A Carpenter, Jason S McLellan, Zhiheng Yu, Reuben S Harris

Abstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Article
  3. Journal of virology · 2026
    Article
  4. Article
  5. HAMMER: Hairpin-based APOBEC3A-mediated mRNA editing reporter.bioRxiv : the preprint server for biology · 2026
    Article
  6. bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nadine M ShabanDepartment of Biochemistry, Molecular Biology, and Biophysics, Institute for Molecular Virology, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-3988-745X
Rui YanJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 55416, USA.ORCID 0000-0002-0167-2816
Ke ShiDepartment of Biochemistry, Molecular Biology, and Biophysics, Institute for Molecular Virology, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Sofia N MoraesDepartment of Biochemistry, Molecular Biology, and Biophysics, Institute for Molecular Virology, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-0838-0047
Adam Z ChengDepartment of Biochemistry, Molecular Biology, and Biophysics, Institute for Molecular Virology, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-6277-9433
Michael A CarpenterHoward Hughes Medical Institute, University of Minnesota, Minneapolis, MN 55416, USA.ORCID 0000-0001-9524-5323
Jason S McLellanDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0003-3991-542X
Zhiheng YuJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 55416, USA.ORCID 0000-0002-7114-2570
Reuben S HarrisDepartment of Biochemistry, Molecular Biology, and Biophysics, Institute for Molecular Virology, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-9034-9112

Funding

PROJECT 3 – BIOLOGY OF DNA DEAMINASES IN CANCERP01CA234228 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Michael Allen Carpenter · 2019 to 2026
$14.5M
Minnesota Training Program in VirologyT32AI083196 · NIAID · UNIVERSITY OF MINNESOTA · PI Louis M Mansky · 2010 to 2026
$3.2M
Structural Studies of APOBEC-Vif ComplexesR56AI150402 · NIAID · UNIVERSITY OF MINNESOTA · PI SHABAN, NADINE M. · 2020 to 2020
$384k
HIV-1 Vif in AIDS-Related MalignanciesF30CA200432 · NCI · UNIVERSITY OF MINNESOTA · PI CHENG, ADAM Z · 2015 to 2019
$213k
A dual role for APOBEC counteraction in EBV infectionF31AI161910 · NIAID · UNIVERSITY OF MINNESOTA · PI MORAES, SOFIA · 2021 to 2021
$8k
NCI NIH HHS F30 CA200432NCI NIH HHS P01 CA234228NIAID NIH HHS F31 AI161910NIAID NIH HHS R56 AI150402NIAID NIH HHS T32 AI083196
6 · The paper itself

Abstract

Viruses use a plethora of mechanisms to evade immune responses. A recent example is neutralization of the nuclear DNA cytosine deaminase APOBEC3B by the Epstein-Barr virus (EBV) ribonucleotide reductase subunit BORF2. Cryo-EM studies of APOBEC3B-BORF2 complexes reveal a large >1000-Å

Identifiers

PMID35476445
PMCPMC9045721

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.