Evidence map›Paper›PMID 35484249›Full record

ArticleNature cell biology2022

Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase.

Glenn F W Walpole, Jonathan Pacheco, Neha Chauhan, Jonathan Clark, Karen E Anderson, Yazan M Abbas, Danielle Brabant-Kirwan, Fernando Montaño-Rendón, Zetao Liu, Hongxian Zhu and 7 more

Open access · greenAbstract read
In one paragraph

Article in Nature cell biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Subcellular Cartography of the Phosphoinositide Multiverse.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Using theBio-protocol · 2025
    Article
  10. Review
  11. Nonlinear dynamics in phosphoinositide metabolism.Current opinion in cell biology · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. iScience · 2023
    Article
  17. Human variation impactingCell genomics · 2023
    Article
  18. International journal of molecular sciences · 2023
    Article
  19. Article
  20. Metagenome diversity illuminates origins of pathogen effectors.bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 3 countries.

Glenn F W WalpoleDivision of Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0001-8502-0892
Jonathan PachecoDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Neha ChauhanKeenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.
Jonathan ClarkSignalling Programme, Babraham Institute, Cambridge, UK.
Karen E AndersonSignalling Programme, Babraham Institute, Cambridge, UK.
Yazan M AbbasMolecular Medicine Program, Hospital for Sick Children, Toronto, Ontario, Canada.
Danielle Brabant-KirwanClinical Microbiology, Health Sciences North-Horizon Santé-Nord, Sudbury, Ontario, Canada.ORCID 0000-0001-5925-306X
Fernando Montaño-RendónDivision of Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
Zetao LiuDivision of Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
Hongxian ZhuDivision of Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
John H BrumellDivision of Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-5802-7789
Alexander DeitersDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA.
Len R StephensSignalling Programme, Babraham Institute, Cambridge, UK.
Phillip T HawkinsSignalling Programme, Babraham Institute, Cambridge, UK.ORCID 0000-0002-6979-0464
Gerald R V HammondDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0002-6660-3272
Sergio GrinsteinDivision of Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada. sergio.grinstein@sickkids.ca.ORCID 0000-0002-0795-4160
Gregory D FairnDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada. gfairn@dal.ca.ORCID 0000-0001-6508-168X
University of Toronto · CABabraham Institute · GBSt. Michael's Hospital · CAUniversity of Pittsburgh · USHealth Sciences North · CAHospital for Sick Children · CA

Funding

Directing Membrane Function with Inositol Lipids in Health and DiseaseR35GM119412 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gerald R Hammond · 2016 to 2026
$4.3M
Principles for Designing Stimulus-Responsive EnzymesR01GM132565 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI KHARE, SAGAR D · 2019 to 2022
$1.8M
Biotechnology and Biological Sciences Research Council BBS/E/B/000C0415NIGMS NIH HHS R01 GM132565NIGMS NIH HHS R35 GM119412
6 · The paper itself

Abstract

Despite their low abundance, phosphoinositides play a central role in membrane traffic and signalling. PtdIns(3,4,5)P

Indexed as

Phosphatidylinositol PhosphatesPhosphatidylinositolsPhosphatidylinositol 3-KinasesPhosphotransferasesSalmonellaSignal TransductionPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhosphatidylinositolsPhosphotransferases

Identifiers

PMID35484249
PMCPMC9107517
OpenAlexW4225112567

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.