Evidence map›Paper›PMID 35484438›Full record

ArticleCellular and molecular life sciences : CMLS2022

Impaired regulation of PMCA activity by defective CFTR expression promotes epithelial cell damage in alcoholic pancreatitis and hepatitis.

Tamara Madácsy, Árpád Varga, Noémi Papp, Bálint Tél, Petra Pallagi, Viktória Szabó, Aletta Kiss, Júlia Fanczal, Zoltan Rakonczay, László Tiszlavicz and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 3 countries.

Tamara MadácsyDepartment of Medicine, University of Szeged, Szeged, 6720, Hungary.
Árpád VargaDepartment of Medicine, University of Szeged, Szeged, 6720, Hungary.
Noémi PappDepartment of Medicine, University of Szeged, Szeged, 6720, Hungary.
Bálint TélDepartment of Medicine, University of Szeged, Szeged, 6720, Hungary.
Petra PallagiDepartment of Medicine, University of Szeged, Szeged, 6720, Hungary.
Viktória SzabóDepartment of Medicine, University of Szeged, Szeged, 6720, Hungary.
Aletta KissDepartment of Medicine, University of Szeged, Szeged, 6720, Hungary.
Júlia FanczalDepartment of Medicine, University of Szeged, Szeged, 6720, Hungary.
Zoltan RakonczayDepartment of Pathophysiology, University of Szeged, Szeged, 6720, Hungary.
László TiszlaviczDepartment of Pathology, University of Szeged, Szeged, Hungary.
Zsolt RázgaDepartment of Pathology, University of Szeged, Szeged, Hungary.
Meike HohwielerDepartment of Internal Medicine I, Ulm University Hospital, Ulm, Germany.
Alexander KlegerDepartment of Internal Medicine I, Ulm University Hospital, Ulm, Germany.
Mike GrayBiosciences Institute, Newcastle University, Newcastle upon Tyne, England.
Péter HegyiInstitute for Translational Medicine, University of Pécs, Pécs, Hungary.
József MaléthDepartment of Medicine, University of Szeged, Szeged, 6720, Hungary. jozsefmaleth1@gmail.com.ORCID http://orcid.org/0000-0001-5768-3090
University of Szeged · HUSemmelweis University · HUUniversity Hospital Ulm · DENewcastle University · GB

Funding

Horizon 2020 739593Magyar Tudományos Akadémia BO/00569/17Magyar Tudományos Akadémia LP2017-18/2017Nemzeti Kutatási Fejlesztési és Innovációs Hivatal 20391-3/2018/FEKUSTRATNemzeti Kutatási Fejlesztési és Innovációs Hivatal FK139269Nemzeti Kutatási Fejlesztési és Innovációs Hivatal PD116553Nemzeti Kutatási Fejlesztési és Innovációs Hivatal UNKP-21-4-SZTE-116University of Szeged, Faculty of Medicine Albert Szent-Gyorgyi Research Grant
6 · The paper itself

Abstract

Alcoholic pancreatitis and hepatitis are frequent, potentially lethal diseases with limited treatment options. Our previous study reported that the expression of CFTR Cl

Indexed as

HepatitisHepatitis, AlcoholicPancreatitis, AlcoholicAnimalsCystic Fibrosis Transmembrane Conductance RegulatorEpithelial CellsEthanolHumansMiceCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorEthanolAlcoholic hepatitisAlcoholic pancreatitisCa2+ signalingCFTREpithelial ion secretion

Identifiers

PMID35484438
PMCPMC11073305
OpenAlexW4225318464

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.