ArticleCommunications biology2022
Incorporating local ancestry improves identification of ancestry-associated methylation signatures and meQTLs in African Americans.
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Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- From Spatial Epigenomes to Clinical Diagnostics: Integrative Methylomics Across Scales and Modalities.International journal of molecular sciences · 2026Review
- Reducing demographic bias in biomedical machine learning for cancer detection using cfDNA methylation.Genome biology · 2026Article
- UBD: incorporating uncertainty in cell type proportion estimates from bulk samples to infer cell-type-specific profiles.Briefings in bioinformatics · 2026Article
- Genetic influences on the association between DNA methylation and obesity measures: insights from a twin study design.Cell & bioscience · 2025Article
- Incorporating local ancestry information to predict genetically associated DNA methylation in admixed populations.Briefings in bioinformatics · 2025Observational
- Opportunities and challenges of local ancestry in genetic association analyses.American journal of human genetics · 2025Review
- Insights from a methylome-wide association study of antidepressant exposure.Nature communications · 2025Article
- Hypermethylation ofJournal of the American Heart Association · 2025Article
- Gene-environment interactions in human health.Nature reviews. Genetics · 2024Review
- HBI: a hierarchical Bayesian interaction model to estimate cell-type-specific methylation quantitative trait loci incorporating priors from cell-sorted bisulfite sequencing data.Genome biology · 2024Article
- Machine learning unveils an immune-related DNA methylation profile in germline DNA from breast cancer patients.Clinical epigenetics · 2024Article
- Reply to: Genetic differentiation at probe SNPs leads to spurious results in meQTL discovery.Communications biology · 2023Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Boyang LiDepartment of Biostatistics, School of Public Health, Yale University, New Haven, CT, United States.ORCID http://orcid.org/0000-0003-2808-9986
Bradley E AouizeratBluestone Center for Clinical Research, New York University, New York, NY, United States.
Youshu ChengDepartment of Biostatistics, School of Public Health, Yale University, New Haven, CT, United States.
Kathryn AnastosDivision of General Internal Medicine, Albert Einstein College of Medicine, Montefiore Health System, Bronx, NY, United States.ORCID http://orcid.org/0000-0002-0769-6405
Amy C JusticeVA Connecticut Healthcare System, US Department of Veterans Affairs, West Haven, CT, United States.ORCID http://orcid.org/0000-0003-0139-5502
Hongyu Zhao *Department of Biostatistics, School of Public Health, Yale University, New Haven, CT, United States. hongyu.zhao@yale.edu.ORCID http://orcid.org/0000-0003-1195-9607
Ke Xu *VA Connecticut Healthcare System, US Department of Veterans Affairs, West Haven, CT, United States. ke.xu@yale.edu.ORCID http://orcid.org/0000-0002-6472-7052
United States Department of Veterans Affairs · USAlbert Einstein College of Medicine · USCenter for Clinical Research (United States) · USYale University · US
Funding
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1MEngaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0MVirology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9MVirology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0MSF Bay Area MACS/WIHS Combined Cohort StudyU01HL146242 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bradley E Aouizerat, Jennifer Cohen Price · 2019 to 2026
$36.3MSex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosisU01HL146193 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Stephen J Gange, Elizabeth Topper · 2019 to 2026
$35.8MSex differences in the role of multi-omics in HIV-associated carotid artery atherosclerosisU01HL146204 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI David B. Hanna, Anjali Sharma · 2019 to 2026
$33.2MMACS/WIHS Combined Cohort Study Clinical Research SiteU01HL146241 · NHLBI · EMORY UNIVERSITY · PI Cecile Delille Lahiri, Anandi Nayan Sheth · 2019 to 2026
$24.2MUAB-MISS MACS/WIHS Combined Cohort StudyU01HL146192 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI James Benjamin Brock, MIRJAM-COLETTE KEMPF · 2019 to 2026
$23.9MMWCCS: Brooklyn Clinical Research SiteU01HL146202 · NHLBI · SUNY DOWNSTATE MEDICAL CENTER · PI TRACEY ELIZABETH WILSON, Jessica Eve Yager · 2019 to 2026
$23.6MSurviving the HIV Epidemic (S/HE) in metropolitan Washington DC - Advancing knowledge through cohort studiesU01HL146205 · NHLBI · GEORGETOWN UNIVERSITY · PI SEBLE G KASSAYE, DANIEL J MERENSTEIN · 2019 to 2026
$23.5MMWCCS: The Chicago Cook County Clinical Research SiteU01HL146245 · NHLBI · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI Audrey French, Ryan Dee Ross · 2019 to 2026
$23.3MNCATS NIH HHS UL1 TR000004NHLBI NIH HHS U01 HL146192NHLBI NIH HHS U01 HL146193NHLBI NIH HHS U01 HL146194NHLBI NIH HHS U01 HL146202NHLBI NIH HHS U01 HL146203NHLBI NIH HHS U01 HL146204NHLBI NIH HHS U01 HL146205NHLBI NIH HHS U01 HL146241NHLBI NIH HHS U01 HL146242NHLBI NIH HHS U01 HL146245NIAAA NIH HHS U01 AA020790NIAAA NIH HHS U01 AA020795NIAAA NIH HHS U01 AA020799NIAAA NIH HHS U10 AA013566NIAAA NIH HHS U24 AA020794NIAID NIH HHS P30 AI027767NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI050410NIDA NIH HHS R01 DA035616NIDA NIH HHS R01 DA038632NIDA NIH HHS R01 DA042691NIDA NIH HHS R01 DA047063NIDA NIH HHS R01 DA047820NIDA NIH HHS R03 DA039745
Abstract
Here we report three epigenome-wide association studies (EWAS) of DNA methylation on self-reported race, global genetic ancestry, and local genetic ancestry in admixed Americans from three sets of samples, including internal and external replications (N
Indexed as
Black or African AmericanQuantitative Trait LociBlack PeopleDNA MethylationHumansPolymorphism, Single NucleotideUnited States
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