SynthesisMaternal & child nutrition2022
Impact of prelacteal feeds and neonatal introduction of breast milk substitutes on breastfeeding outcomes: A systematic review and meta-analysis.
Synthesis in Maternal & child nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Risk factors for self-reported insufficient milk during the first 6 months of life: A systematic review.Maternal & child nutrition · 2022Pooled it
- Impact of prelacteal feeds and neonatal introduction of breast milk substitutes on breastfeeding outcomes: A systematic review and meta-analysis.Maternal & child nutrition · 2022Pooled it
- Factors Associated With Prelacteal Feeding of Commercial Milk Formula: An Analysis of Cohort Data From the BADUTA Study in Indonesia.Maternal & child nutrition · 2025Trial
- Informal Human Milk Sharing: The Experiences and Practices of Informal Human Milk Sharing in Ireland.Maternal & child nutrition · 2026Article
- Exclusive Breastfeeding and Growth Trajectories Until 5 Years of Age Among Children Monitored in Primary Health Care in Brazil.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- Breastfeeding practices among foreign-born non-Hispanic mothers of children in the United States - a cross-sectional study of nationwide multi-year data.BMC pregnancy and childbirth · 2026Article
- A ducted, biomimetic nipple replicates breastfeeding mechanics through ontogeny in an infant animal model.Pediatric research · 2026Article
- The effect of IV fluid supplementation and feeding method on bilirubin elimination in term neonates with severe indirect hyperbilirubinemia: a retrospective cohort study.Frontiers in pediatrics · 2026Article
- Trends and determinants of prelacteal feeding practice in rural Bangladesh from 2004 to 2019: A multivariate decomposition analysis.PloS one · 2026Article
- Programming the Infant Gut: How Maternal and Early Life Nutrition Shape the Infant Microbiome and Long-term Health-A Narrative Review.Molecular nutrition & food research · 2026Review
- Global, regional, and national progress towards the 2030 global nutrition targets and forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2021.Lancet (London, England) · 2025Article
- Pre-lacteal feeding practices and associated factors among mothers of children under 24 months age in Ethiopia: A geo-additive model approach.BMC public health · 2025Article
- Factors influencing infant feeding practices of Indian immigrant mothers in Australia-a qualitative exploratory study.Archives of public health = Archives belges de sante publique · 2025Article
- A Descriptive Investigation of Infant Feeding Bottles Marketed in the UK Designed to Replicate Breastfeeding and the Evidence That Underpins Them.Maternal & child nutrition · 2025Article
- The global burden of suboptimal breastfeeding from 1990 to 2019: results and insights of the Global Burden of Disease.European journal of pediatrics · 2025Article
- Association Between Breastfeeding Intensity and Mammary Gland Involution Markers in Early Postpartum Among Women from Low-Income Households.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2025Article
- Microplastic and human health with focus on pediatric well-being: a comprehensive review and call for future studies.Clinical and experimental pediatrics · 2025Article
- Exploring factors that influence the knowledge and awareness of breastfeeding among Saudi mothers: a qualitative study.Frontiers in nutrition · 2025Article
- What is effective communication in breastfeeding care? Perspectives from Latina women.PloS one · 2025Article
- Exploring the factors associated with prelacteal feeds in Papua New Guinea: a population-based survey.BMJ open · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The introduction of fluids other than breast milk during the first few days of life or later neonatal period has been identified as a risk factor for suboptimal breastfeeding (BF) outcomes in numerous studies using varying study designs. However, the relationship between early introduction of fluids other than breast milk and BF outcomes has not been systematically assessed using only prospective studies that can establish temporality, which is critical for determining whether observed associations are causal. We conducted a systematic review and meta-analysis of prospective studies to assess if there is a difference in BF outcomes as a result of the introduction of: (a) milk-based prelacteals, (b) water-based prelacteals and (c) breast milk substitutes (BMS) between 4 days and 4 weeks postpartum. We searched PubMed, Lilacs, Web of Science and other repositories for original research investigating the relationship between early introduction of prelacteals and/or BMS and BF outcomes. Forty-eight studies met the inclusion criteria for the systematic review. Of the 39 prelacteal feeding studies, 27 had the prerequisite statistical information for inclusion in the meta-analysis. Findings from the meta-analysis showed a relationship between prelacteals and exclusive BF cessation (RR 1.44; 1.29-1.60) and any BF cessation (2.23; 1.63-3.06) among infants under 6 months old. Nine studies focusing on the introduction of BMS during the neonatal period identified this practice as a statistically significant risk factor for a shorter BF duration. Effective interventions are needed to prevent the introduction of unnecessary milk-based prelacteals and BMS during the perinatal and neonatal periods to improve BF outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.