ArticleBiological psychiatry2022
Virtual Ontogeny of Cortical Growth Preceding Mental Illness.
Open access · greenAbstract read
In one paragraph
Article in Biological psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Genetic and phenotypic similarity across major psychiatric disorders: a systematic review and quantitative assessment.Translational psychiatry · 2024Pooled it
- Genetic Influences on the Developing Young Brain and Risk for Neuropsychiatric Disorders.Biological psychiatry · 2023Pooled it
- Big data and psychiatry: advances, constraints and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Sex differences in 5-year incidence and prevalence of physical illnesses following early childhood autism diagnosis.JCPP advances · 2026Article
- Cross-disorder comparison of brain structures among 4836 individuals with mental disorders and controls utilizing danish population-based clinical MRI scans.Molecular psychiatry · 2026Article
- Prenatal and early-life determinants of neurodevelopment: A decade of discoveries and new directions in ABCD.Developmental cognitive neuroscience · 2026Review
- The tangential growth of the human visual cortex and maternal smoking during pregnancy.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Copy number variants reveal divergent genetic and diagnostic cortical signatures across psychiatric disorders.Research square · 2026Article
- Recent developments in imaging transcriptomics for psychiatric disorders.Psychoradiology · 2026Review
- Mapping Structural Neuroimaging Trajectories in Bipolar Disorder: Neurobiological and Clinical Implications.Biological psychiatry · 2025Review
- Genetic Interplay Between Attention-Deficit/Hyperactivity Disorder and Pain Suggests Neurodevelopmental Pathways and Comorbidity Risk.Biological psychiatry global open science · 2025Article
- Cortical differences across psychiatric disorders and associated common and rare genetic variants.medRxiv : the preprint server for health sciences · 2025Article
- Copy number variants and the tangential expansion of the cerebral cortex.Nature communications · 2025Article
- Prenatal exposure to green space and mental health in early adolescence: findings from the TRAILS study.American journal of epidemiology · 2024Article
- Unraveling the molecular relevance of brain phenotypes: A comparative analysis of null models and test statistics.NeuroImage · 2024Article
- Article
- Intrauterine growth and the tangential expansion of the human cerebral cortex in times of food scarcity and abundance.Nature communications · 2024Article
- Population Neuroscience: Principles and Advances.Current topics in behavioral neurosciences · 2024Review
- Transcriptomics : Approaches to Quantifying Gene Expression and Their Application to Studying the Human Brain.Current topics in behavioral neurosciences · 2024Review
- Large-Scale Neuroimaging of Mental Illness.Current topics in behavioral neurosciences · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
196 authors at 20 institutions in 19 countries.
Yash PatelInstitute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.
Jean ShinThe Hospital for Sick Children and Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.
Christoph AbéDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Ingrid AgartzNORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Clara AllozaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria del Hospital Gregorio Marañón, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
Dag AlnæsNORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Sonia AmbrogiLaboratory of Neuropsychiatry, Santa Lucia Foundation Scientific Institute for Research, Hospitalization and Healthcare, Rome, Italy.
Linda A AntonucciDepartments of Education Science, Psychology, Communication Science, University of Bari Aldo Moro, Bari, Italy.
Celso ArangoDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria del Hospital Gregorio Marañón, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain; School of Medicine, Universidad Complutense, Madrid, Spain.
Volker AroltInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Guillaume AuziasNational Centre for Scientific Research, Aix-Marseille University, Marseille, France.
Rosa Ayesa-ArriolaDepartment of Psychiatry, Marques de Valdecilla University Hospital, Instituto de Investigación Valdecilla, CIBERSAM, School of Medicine, University of Cantabria, Santander, Spain.
Nerisa BanajLaboratory of Neuropsychiatry, Santa Lucia Foundation Scientific Institute for Research, Hospitalization and Healthcare, Rome, Italy.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Cibele BandeiraDepartment of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Zeynep BaşgözeDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, Minnesota.
Renata Basso CupertinoDepartment of Psychiatry, University of Vermont, Burlington, Vermont.
Claiton H D BauDepartment of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Jochen BauerDepartment of Clinical Radiology, University of Münster, Münster, Germany.
Sarah BaumeisterDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Fabio BernardoniTranslational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Germany.
Alessandro BertolinoBasic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
Caterina Del Mar BonninInstitut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.
Daniel BrandeisDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Silvia BremDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zürich, Zurich, Switzerland.
Jason BruggemannSchool of Psychiatry, Sydney, Australia.
Robin BülowInstitute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
Juan R BustilloDepartment of Psychiatry, University of New Mexico, Albuquerque, New Mexico.
Sara CalderoniDepartment of Developmental Neuroscience, Scientific Institute for Research, Hospitalization and Healthcare Stella Maris Foundation, Pisa, Italy.
Rosa CalvoInstitute of Neuroscience, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, CIBERSAM, Barcelona, Spain.
Erick J Canales-RodríguezFIDMAG Research Foundation, Barcelona, Spain.
Dara M CannonClinical Neuroimaging Lab, Center for Neuroimaging, Cognition and Genomics, Galway Neuroscience Centre, College of Medicine, Nursing, and Health Sciences, National University of Ireland Galway, Galway, Ireland.
Susanna CarmonaInstituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
Vaughan J CarrSchool of Psychiatry, Sydney, Australia.
Stanley V CattsSchool of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Sneha ChenjiDepartment of Psychiatry, University of Calgary, Calgary, Alberta, Canada.
Qian Hui ChewResearch Division, Institute of Mental Health, Singapore, Singapore.
David CoghillDepartment of Paediatrics, Department of Psychiatry, University of Melbourne, Parkville, Australia; Department of Psychiatry, Department of Psychiatry, University of Melbourne, Parkville, Australia.
Colm G ConnollyDepartment of Biomedical Sciences, Florida State University, Tallahassee, Florida.
Annette ConzelmannDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Tübingen, Tübingen, Germany.
Alexander R CravenDepartment of Biological and Medical Psychology, University of Bergen, Bergen, Norway.
Benedicto Crespo-FacorroDepartment of Psychiatry, Virgen del Rocio University Hospital, Universidad de Sevilla, Instituto de Biomedicina de Sevilla, CIBERSAM, Sevilla, Spain.
Kathryn CullenDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, Minnesota.
Andreas DahlDepartment of Psychology, University of Oslo, Oslo, Norway.
Udo DannlowskiInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Christopher G DaveyDepartment of Psychiatry, Department of Psychiatry, University of Melbourne, Parkville, Australia.
Christine DeruelleNational Centre for Scientific Research, Aix-Marseille University, Marseille, France.
Covadonga M Díaz-CanejaSchool of Medicine, Universidad Complutense, Madrid, Spain.
Katharina DohmInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Stefan EhrlichTranslational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Germany.
Jeffery EpsteinCincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Tracy Erwin-GrabnerLaboratory of Systems Neuroscience and Imaging in Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
Lisa T EylerDepartment of Psychiatry, University of California San Diego, San Diego, California.
Jennifer FedorDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
Jacqueline FitzgeraldTrinity Institute of Neuroscience, School of Medicine, Trinity College Dublin, Dublin, Ireland.
William ForanDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
Judith M FordSan Francisco Veterans Affairs Medical Center, San Francisco, California.
Lydia ForteaInstitut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.
Paola Fuentes-ClaramonteFIDMAG Research Foundation, Barcelona, Spain.
Janice FullertonNeuroscience Research Australia, Sydney, Australia.
Lisa FurlongMelbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Parkville, Australia.
Louise GallagherDiscipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland.
Bingchen GaoClinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California.
Si GaoMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland.
Jose M GoikoleaInstitut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.
Ian GotlibDepartment of Psychology, Stanford University, Stanford, California.
Roberto Goya-MaldonadoLaboratory of Systems Neuroscience and Imaging in Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Melissa GreenSchool of Psychiatry, Sydney, Australia.
Eugenio H GrevetDepartment of Psychiatry, Faculty of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Nynke A GroenewoldDepartment of Psychiatry & Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Dominik GrotegerdInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Oliver GruberSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany.
Jan HaavikDepartment of Biomedicine, University of Bergen, Bergen, Norway.
Tim HahnInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Ben J HarrisonMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.
Walter HeindelDepartment of Clinical Radiology, University of Münster, Münster, Germany.
Frans HenskensSchool of Medicine & Public Health, The University of Newcastle, Callaghan, New South Wales, Australia.
Dirk J HeslenfeldExperimental and Clinical Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Eva HillandNorwegian Centre for Mental Disorders Research NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Pieter J HoekstraDepartment of Child and Adolescent Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Sarah HohmannDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Nathalie HolzDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Fleur M HowellsDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Jonathan C IpserDepartment of Psychiatry & Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Neda JahanshadUSC Mark and Mary Stevens Neuroimaging and Informatics Institute, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, University of Southern California, Marina del Rey, California.
Babette JakobiDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands.
Andreas JansenCore Facility Brain imaging, Faculty of Medicine, University of Marburg, Marburg, Germany.
Joost JanssenDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria del Hospital Gregorio Marañón, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
Rune JonassenFaculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway.
Anna KaiserDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Vasiliy KaledaMental Health Research Center, Moscow, Russia.
James KarantonisMelbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Parkville, Australia.
Joseph A KingTranslational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Germany.
Tilo KircherDepartment of Psychiatry, Marburg University, Marburg, Germany.
Peter KochunovMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland.
Sheri-Michelle KoopowitzDepartment of Psychiatry & Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Mikael LandénInstitute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
Nils Inge LandrøDepartment of Psychology, University of Oslo, Oslo, Norway.
Stephen LawrieDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Irina LebedevaMental Health Research Center, Moscow, Russia.
Beatriz LunaDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
Astri J LundervoldDepartment of Biological and Medical Psychology, University of Bergen, Bergen, Norway.
Frank P MacMasterDepartments of Psychiatry and Pediatrics, University of Calgary, Calgary, Alberta, Canada.
Luigi A MaglanocDepartment for Data Capture and Collections Management, University Center for Information Technology, University of Oslo, Oslo, Norway.
Daniel H MathalonDepartment of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, California.
Colm McDonaldGalway Neuroscience Centre, Center for Neuroimaging, Cognition and Genomics, Galway Neuroscience Centre, College of Medicine, Nursing, and Health Sciences, National University of Ireland Galway, Galway, Ireland.
Andrew McIntoshDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Susanne MeinertInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Patricia T MichieSchool of Psychology, College of Engineering, Science and Environment, The University of Newcastle, Callaghan, New South Wales, Australia.
Philip MitchellSchool of Psychiatry, Sydney, Australia.
Ana Moreno-AlcázarFIDMAG Germanes Hospitalàries Research Foundation, Biomedical Network Research Centre on Mental Health (CIBERSAM), Barcelona, Spain.
Bryan MowryQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
Filippo MuratoriDepartment of Developmental Neuroscience, Scientific Institute for Research, Hospitalization and Healthcare Stella Maris Foundation, Pisa, Italy.
Leila NabulsiClinical Neuroimaging Lab, Center for Neuroimaging, Cognition and Genomics, Galway Neuroscience Centre, College of Medicine, Nursing, and Health Sciences, National University of Ireland Galway, Galway, Ireland.
Igor NenadićDepartment of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Marburg, Germany.
Ruth O'Gorman TuuraUniversity Children's Hospital Zürich, Zurich, Switzerland.
Jaap OosterlaanClinical Neuropsychology Section, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Bronwyn OversNeuroscience Research Australia, Sydney, Australia.
Christos PantelisMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Carlton South, Victoria, Australia.
Mara ParelladaSchool of Medicine, Universidad Complutense, Madrid, Spain.
Jose C ParienteMagnetic Resonance Imaging core facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
Paul PauliDepartment of Psychology (Biological Psychology, Clinical Psychology, and Psychotherapy), University of Würzburg, Würzburg, Germany.
Giulio PergolaBasic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
Francesco Maria PiarulliBasic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
Felipe PiconGraduate Program in Psychiatry and Behavioral Sciences, Faculty of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Fabrizio PirasLaboratory of Neuropsychiatry, Santa Lucia Foundation Scientific Institute for Research, Hospitalization and Healthcare, Rome, Italy.
Edith Pomarol-ClotetFIDMAG Research Foundation, Barcelona, Spain.
Clara PretusDepartment of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
Yann QuidéSchool of Psychiatry, Sydney, Australia.
Joaquim RaduaInstitut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.
J Antoni Ramos-QuirogaDepartment of Psychiatry, Hospital Universitari Vall d'Hebrón, CIBERSAM, Universitat Autònoma de Barcelona, Barcelona, Spain.
Paul E RasserPriority Centre for Brain & Mental Health Research, The University of Newcastle, Callaghan, New South Wales, Australia.
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt-Goethe University, Frankfurt am Main, Germany.
Alessandra ReticoNational Institute for Nuclear Physics, Pisa Division, Pisa, Italy.
Gloria RobertsSchool of Psychiatry, Sydney, Australia.
Susan RossellCentre for Mental Health, School of Health Sciences, Swinburne University, Melbourne, Victoria, Australia.
Diego Luiz RovarisDepartment of Physiology and Biophysics, Instituto de Ciencias Biomédicas Universidade de São Paulo, São Paulo, Brazil.
Katya RubiaChild & Adolescent Psychiatry, King's College London, London, United Kingdom.
Matthew SacchetCenter for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont, Massachusetts.
Josep SalavertFIDMAG Germanes Hospitalàries Research Foundation, Biomedical Network Research Centre on Mental Health (CIBERSAM), Barcelona, Spain.
Raymond SalvadorFIDMAG Research Foundation, Barcelona, Spain.
Salvador SarróFIDMAG Research Foundation, Barcelona, Spain.
Akira SawaJohns Hopkins University School of Medicine, Baltimore, Maryland.
Ulrich SchallPriority Centre for Brain & Mental Health Research, The University of Newcastle, Callaghan, New South Wales, Australia.
Rodney ScottHunter Medical Research Institute, Newcastle, New South Wales, Australia.
Pierluigi SelvaggiAzienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Bari, Italy.
Tim SilkSchool of Psychology, Deakin University, Geelong, Victoria, Australia.
Kang SimWest Region, Institute of Mental Health, Singapore, Singapore.
Antonin SkochNational Institute of Mental Health, Klecany, Czech Republic.
Gianfranco SpallettaLaboratory of Neuropsychiatry, Santa Lucia Foundation Scientific Institute for Research, Hospitalization and Healthcare, Rome, Italy.
Filip SpanielNational Institute of Mental Health, Klecany, Czech Republic.
Dan J SteinDepartment of Psychiatry & Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Olaf SteinsträterDepartment of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Marburg, Germany.
Aleks StolicynDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Yoichiro TakayanagiDepartment of Neuropsychiatry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Leanne TammCincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Maria TavaresDepartment of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Katharina ThielInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Sophia I ThomopoulosImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, University of Southern California, Marina del Rey, California.
David TomecekNational Institute of Mental Health, Klecany, Czech Republic.
Alexander S TomyshevMental Health Research Center, Moscow, Russia.
Diana Tordesillas-GutiérrezDepartment of Radiology, University Hospital Marqués de Valdecilla, Instituto de Investigación Valdecilla, Santander, Spain.
Michela TosettiLaboratory of Medical Physics and Magnetic Resonance, Scientific Institute for Research, Hospitalization and Healthcare Stella Maris Foundation, Pisa, Italy.
Anne UhlmannDepartment of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Germany.
Tamsyn Van RheenenMelbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne, Australia.
Javier Vazquez-BourgónDepartment of Psychiatry, Marques de Valdecilla University Hospital, Instituto de Investigación Valdecilla, CIBERSAM, School of Medicine, University of Cantabria, Santander, Spain.
Meike W VernooijDepartment of Radiology & Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
Eduard VietaInstitute of Neuroscience, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, CIBERSAM, Barcelona, Spain.
Oscar VilarroyaDepartment of Psychiatry, Autonomous University of Barcelona, Cerdanyola del Valles, Spain.
Cynthia WeickertDepartment of Neuroscience and Physiology, University of New South Wales, Sydney, Australia.
Thomas WeickertSUNY Upstate Medical University, Syracuse, New York.
Lars T WestlyeNORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Heather WhalleyDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
David WillingerDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital, University of Zürich, Zurich, Switzerland.
Alexandra WinterInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Katharina WittfeldGerman Center for Neurodegenerative Diseases, Site Rostock/Greifswald, Greifswald, Germany.
Tony T YangDepartment of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, University of California San Francisco, San Francisco, California.
Yuliya YonchevaNYU Grossman School of Medicine, New York, New York.
Jendé L ZijlmansDepartment of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
Martine HoogmanDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands.
Barbara FrankeDepartments of Human Genetics and Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands.
Daan van RooijDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands.
Jan BuitelaarDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands.
Christopher R K ChingImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, University of Southern California, Marina del Rey, California.
Ole A AndreassenNORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Elena PozziCentre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
Dick VeltmanDepartment of Psychiatry, Amsterdam UMC, VUMC, Amsterdam, The Netherlands.
Lianne SchmaalCentre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
Theo G M van ErpClinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California.
Jessica TurnerGeorgia State University, Atlanta, Georgia.
F Xavier CastellanosNYU Grossman School of Medicine, New York, New York.
Zdenka PausovaThe Hospital for Sick Children and Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.
Paul ThompsonImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, University of Southern California, Marina del Rey, California.
Tomas PausInstitute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada; Departments of Psychiatry and Neuroscience, Faculty of Medicine and Centre Hospitalier Universitaire Sainte-Justine, University of Montréal, Montreal, Quebec, Canada. Electronic address: tpausresearch@gmail.com.
University of Münster · DEThe University of Melbourne · AUCentro de Investigación Biomédica en Red de Salud Mental · ESHeidelberg University · DEFidmag Sisters Hospitallers · ESRadboud University Nijmegen · NLUniversidade Federal do Rio Grande do Sul · BRUniversity of Cape Town · ZAFondazione Santa Lucia · ITOslo University Hospital · NOPhilipps University of Marburg · DEUniversity of Bari Aldo Moro · ITUniversity of Edinburgh · GBUniversity of Newcastle Australia · AUUniversity of Oslo · NOUniversity of Southern California · USUniversity of Toronto · CAFondazione Stella Maris · ITHospital General Universitario Gregorio Marañón · ESMental Health Research Center of Russian Academy of Medical Sciences · RU
Funding
Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1MABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7MABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5MAdolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5MABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7MProspective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2MABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7MFUNCTION BIRNU24RR021992 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI POTKIN, STEVEN G · 2006 to 2010
$25.0MABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9MFIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South FloridaU01DA041156 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI Raul Gonzalez, Angela R Laird · 2015 to 2026
$22.8MABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3MProject 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2011 to 2020
$19.9MMedical Research Council MC_PC_17209NCATS NIH HHS UL1 TR001872NCCIH NIH HHS R21 AT009173NCCIH NIH HHS R61 AT009864NCRR NIH HHS P41 RR008079NCRR NIH HHS U24 RR021992NCRR NIH HHS U24 RR025736NIAAA NIH HHS R01 AA012207NIA NIH HHS T32 AG058507NIBIB NIH HHS R01 EB015611NIBIB NIH HHS U54 EB020403NIDA NIH HHS HHSN271200800009CNIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U01 DA050987NIDA NIH HHS U01 DA050988NIDA NIH HHS U01 DA050989NIDA NIH HHS U01 DA051016NIDA NIH HHS U01 DA051018NIDA NIH HHS U01 DA051037NIDA NIH HHS U01 DA051038NIDA NIH HHS U01 DA051039NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147NIH HHS S10 OD023696NIMH NIH HHS K23 MH090421NIMH NIH HHS P50 MH094268NIMH NIH HHS R01 MH083968NIMH NIH HHS R01 MH085734NIMH NIH HHS R01 MH105660NIMH NIH HHS R01 MH107730NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH116948NIMH NIH HHS R01 MH117601NIMH NIH HHS R01 MH121246NIMH NIH HHS R01 MH133812NIMH NIH HHS R37 MH101495NIMH NIH HHS RF1 MH123163NIMH NIH HHS U01 MH108148NINDS NIH HHS R01 NS114628NINDS NIH HHS RF1 NS114628Wellcome Trust
Abstract
backgroundMorphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental origins mostly undetermined. Deviations in the tangential growth of the cerebral cortex during pre/perinatal periods may be reflected in individual variations in cortical surface area later in life.
methodsInterregional profiles of group differences in surface area between cases and controls were generated using T1-weighted magnetic resonance imaging from 27,359 individuals including those with attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, schizophrenia, and high general psychopathology (through the Child Behavior Checklist). Similarity of interregional profiles of group differences in surface area and prenatal cell-specific gene expression was assessed.
resultsAcross the 11 cortical regions, group differences in cortical area for attention-deficit/hyperactivity disorder, schizophrenia, and Child Behavior Checklist were dominant in multimodal association cortices. The same interregional profiles were also associated with interregional profiles of (prenatal) gene expression specific to proliferative cells, namely radial glia and intermediate progenitor cells (greater expression, larger difference), as well as differentiated cells, namely excitatory neurons and endothelial and mural cells (greater expression, smaller difference). Finally, these cell types were implicated in known pre/perinatal risk factors for psychosis. Genes coexpressed with radial glia were enriched with genes implicated in congenital abnormalities, birth weight, hypoxia, and starvation. Genes coexpressed with endothelial and mural genes were enriched with genes associated with maternal hypertension and preterm birth.
conclusionsOur findings support a neurodevelopmental model of vulnerability to mental illness whereby prenatal risk factors acting through cell-specific processes lead to deviations from typical brain development during pregnancy.
Indexed as
Attention Deficit Disorder with HyperactivityAutism Spectrum DisorderBipolar DisorderMajor Depressive DisorderPremature BirthCerebral CortexChildFemaleHumansInfant, NewbornMagnetic Resonance ImagingPregnancyCortical growthCortical surface areaMental illnessNeurodevelopmentNeurogenesisPsychiatric disorders
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