Evidence map›Paper›PMID 35490640›Full record

ArticlePsychoneuroendocrinology2022

Extracellular matrix metalloproteinase-9 (MMP-9) is required in female mice for 17β-estradiol enhancement of hippocampal memory consolidation.

Kellie S Gross, Carnita M Lincoln, McKenna M Anderson, Grace E Geiger, Karyn M Frick

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Neurotrauma reports · 2025
    Article
  4. Article
  5. Biomarkers and the outcomes of ischemic stroke.Frontiers in molecular neuroscience · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kellie S GrossDepartment of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA.
Carnita M LincolnDepartment of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA.
McKenna M AndersonDepartment of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA.
Grace E GeigerDepartment of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA.
Karyn M FrickDepartment of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA. Electronic address: frickk@uwm.edu.
University of Wisconsin–Milwaukee · US

Funding

Mechanisms underlying memory regulation by 17beta-estradiol, canonical Wnt signaling, and BDNF in male and female miceR01MH107886 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI FRICK, KARYN M · 2016 to 2020
$1.9M
Development of ER-beta Agonists to Treat Post-Menopausal Memory DeclineR15GM118304 · NIGMS · CONCORDIA UNIVERSITY WISCONSIN · PI SEM, DANIEL S · 2015 to 2018
$820k
The role of extracellular matrix in estradiol regulation of hippocampal memory consolidationF32MH118782 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI GROSS, KELLIE · 2019 to 2021
$195k
NIGMS NIH HHS R15 GM118304NIMH NIH HHS F32 MH118782NIMH NIH HHS R01 MH107886
6 · The paper itself

Abstract

Hippocampal plasticity and memory are modulated by the potent estrogen 17β-estradiol (E

Indexed as

Memory ConsolidationAnimalsEstradiolFemaleHippocampusMatrix Metalloproteinase 9MiceMice, Inbred C57BLEstradiolMatrix Metalloproteinase 9EstrogenExtracellular matrixHippocampusMouseObject recognitionSpatial memory

Identifiers

PMID35490640
PMCPMC9173600
OpenAlexW4224217396

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.