Evidence map›Paper›PMID 35490782›Full record

ArticleThe Journal of biological chemistry2022

Enhanced Orai1-mediated store-operated Ca

Yu Tao, Sarika Chaudhari, Parisa Yazdizadeh Shotorbani, Yanfeng Ding, Zhenglan Chen, Ramesh Kasetti, Gulab Zode, Rong Ma

Open access · goldAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. I-mfa, Mesangial Cell TRPC1 Channel, and Regulation of GFR.Journal of the American Society of Nephrology : JASN · 2025
    Article
  4. Inflammation in glomerular diseases.Frontiers in immunology · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Non-voltage-gated CaAmerican journal of physiology. Renal physiology · 2024
    Review
  9. Calcium signalling and transport in the kidney.Nature reviews. Nephrology · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. TFAM and Mitochondrial Protection in Diabetic Kidney Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Review
  14. Store-operated CaAmerican journal of physiology. Renal physiology · 2023
    Article
  15. Store-operated CaExperimental biology and medicine (Maywood, N.J.) · 2023
    Review
  16. Article
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yu TaoDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Sarika ChaudhariDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Parisa Yazdizadeh ShotorbaniDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Yanfeng DingDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Zhenglan ChenDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Ramesh KasettiThe North Texas Eye Research Institute and Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Gulab ZodeThe North Texas Eye Research Institute and Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Rong MaDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA. Electronic address: Rong.Ma@unthsc.edu.
University of North Texas Health Science Center · USUniversity of North Texas · US

Funding

Crosstalk Between Unfolded Protein Response and Autophagy for the Treatment of GlaucomaR01EY026177 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ZODE, GULAB · 2016 to 2025
$3.8M
Targeting ER Stress Pathway Using Sodium 4-Phenylbutyrate for the Treatment of POAGR01EY028616 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ZODE, GULAB · 2018 to 2021
$1.4M
Store-operated Ca2+ signaling in kidney glomerular mesangial cellsR01DK115424 · NIDDK · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI MA, RONG · 2018 to 2021
$1.3M
NEI NIH HHS R01 EY026177NEI NIH HHS R01 EY028616NIDDK NIH HHS R01 DK115424
6 · The paper itself

Abstract

Podocyte injury induced by hyperglycemia is the main cause of kidney dysfunction in diabetic nephropathy. However, the underlying mechanism is unclear. Store-operated Ca

Indexed as

ORAI1 ProteinPodocytesCalciumCalcium ChannelsCalcium SignalingCalpainGlucoseHumansNeoplasm ProteinsStromal Interaction Molecule 1CalciumCalcium ChannelsCalpainGlucoseNeoplasm ProteinsORAI1 ProteinORAI1 protein, humanStromal Interaction Molecule 1calcium release-activated calcium channel protein 1 (ORAI1)calpainCRISPR-Cas9diabetic nephropathypodocyte

Identifiers

PMID35490782
PMCPMC9136128
OpenAlexW4225137603

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.