Evidence map›Paper›PMID 35491946›Full record

ArticleEuropean journal of immunology2022

ICAP-1 loss impairs CD8

Silvia Sevilla-Movilla, Patricia Fuentes, Yaiza Rodríguez-García, Nohemi Arellano-Sánchez, Peter W Krenn, Soledad Isern de Val, Sara Montero-Herradón, Javier García-Ceca, Valeria Burdiel-Herencia, Sofía R Gardeta and 11 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 9 institutions in 4 countries.

Silvia Sevilla-MovillaDepartment of Molecular Biomedicine, Centro de Investigaciones Biológicas Margarita Salas (CSIC), Madrid, Spain.
Patricia FuentesDevelopment and Function of the Immune System Unit, Centro de Biología Molecular Severo Ochoa, CSIC, Universidad Autónoma de Madrid, Madrid, Spain.
Yaiza Rodríguez-GarcíaDepartment of Molecular Biomedicine, Centro de Investigaciones Biológicas Margarita Salas (CSIC), Madrid, Spain.
Nohemi Arellano-SánchezDepartment of Molecular Biomedicine, Centro de Investigaciones Biológicas Margarita Salas (CSIC), Madrid, Spain.
Peter W KrennDepartment of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany.
Soledad Isern de ValDepartment of Molecular Biomedicine, Centro de Investigaciones Biológicas Margarita Salas (CSIC), Madrid, Spain.
Sara Montero-HerradónDepartment of Cell Biology, Faculty of Biology, Complutense University of Madrid, Madrid.
Javier García-CecaDepartment of Cell Biology, Faculty of Biology, Complutense University of Madrid, Madrid.
Valeria Burdiel-HerenciaDepartment of Molecular Biomedicine, Centro de Investigaciones Biológicas Margarita Salas (CSIC), Madrid, Spain.
Sofía R GardetaDepartment on Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC, Madrid, Spain.
Noemí Aguilera-MontillaDepartment of Molecular Biomedicine, Centro de Investigaciones Biológicas Margarita Salas (CSIC), Madrid, Spain.
Celia Barrio-AlonsoDepartment of Molecular Biomedicine, Centro de Investigaciones Biológicas Margarita Salas (CSIC), Madrid, Spain.
Georgiana CrainiciucHospital General Universitario Gregorio Marañón, Madrid, Spain.
Daniel BouvardCentre de Recherche en Biologie Cellulaire de Montpellier, Montpellier, France.
Angeles García-PardoDepartment of Molecular Biomedicine, Centro de Investigaciones Biológicas Margarita Salas (CSIC), Madrid, Spain.
Agustin G ZapataDepartment of Cell Biology, Faculty of Biology, Complutense University of Madrid, Madrid.
Andrés HidalgoInstitute for Cardiovascular Prevention, Ludwig-Maximilians University, Munich, 80336, Germany.
Reinhard FässlerDepartment of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany.
Yolanda R CarrascoDepartment on Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC, Madrid, Spain.
Maria L ToribioDevelopment and Function of the Immune System Unit, Centro de Biología Molecular Severo Ochoa, CSIC, Universidad Autónoma de Madrid, Madrid, Spain.
Joaquin TeixidóDepartment of Molecular Biomedicine, Centro de Investigaciones Biológicas Margarita Salas (CSIC), Madrid, Spain.ORCID 0000-0002-3177-4151
Centro de Investigaciones Biológicas Margarita Salas · ESUniversidad Complutense de Madrid · ESCentro de Biología Molecular Severo Ochoa · ESCentro Nacional de Biotecnología · ESSpanish National Centre for Cardiovascular Research · ESCentre Occitanie-Montpellier · FRHospital General Universitario Gregorio Marañón · ESMax Planck Institute of Biochemistry · DEUniversity of Salzburg · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ICAP-1 regulates β1-integrin activation and cell adhesion. Here, we used ICAP-1-null mice to study ICAP-1 potential involvement during immune cell development and function. Integrin α4β1-dependent adhesion was comparable between ICAP-1-null and control thymocytes, but lack of ICAP-1 caused a defective single-positive (SP) CD8

Indexed as

Adaptor Proteins, Signal TransducingB-LymphocytesCD8-Positive T-LymphocytesLymphocyte ActivationThymocytesAnimalsCell DifferentiationIntegrin beta1MiceMice, KnockoutSpleenThymus GlandAdaptor Proteins, Signal TransducingIntegrin beta1Itgb1bp1 protein, mouseB- cell maturationcell adhesionICAP-1integrinsthymocyte development

Identifiers

PMID35491946
PMCPMC9543158
OpenAlexW4225263899

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.