Evidence map›Paper›PMID 35492879›Full record

SynthesisCell reports. Medicine2022

A multi-level investigation of the genetic relationship between endometriosis and ovarian cancer histotypes.

Sally Mortlock, Rosario I Corona, Pik Fang Kho, Paul Pharoah, Ji-Heui Seo, Matthew L Freedman, Simon A Gayther, Matthew T Siedhoff, Peter A W Rogers, Ronald Leuchter and 8 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cell reports. Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
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  17. Review
  18. Müllerian anomalies and endometriosis: associations and phenotypic variations.Reproductive biology and endocrinology : RB&E · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 3 countries.

Sally MortlockThe Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Rosario I CoronaWomen's Cancer Research Program at Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Pik Fang KhoDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Paul PharoahCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN Cambridge, UK.
Ji-Heui SeoDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Matthew L FreedmanDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Simon A GaytherCenter for Bioinformatics and Functional Genomics, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Matthew T SiedhoffDivision of Minimally Invasive Gynecologic Surgery, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Peter A W RogersUniversity of Melbourne Department of Obstetrics and Gynaecology, and Gynaecology Research Centre, Royal Women's Hospital, Parkville, VIC 3052, Australia.
Ronald LeuchterDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Christine S WalshDepartment of Obstetrics and Gynecology, University of Colorado, Aurora, CO, USA.
Ilana CassDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Beth Y KarlanDepartment of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
B J RimelDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Ovarian Cancer Association Consortium, International Endometriosis Genetics Consortium
Grant W MontgomeryThe Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Kate LawrensonWomen's Cancer Research Program at Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Siddhartha P KarMedical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN Bristol, UK.
Cedars-Sinai Medical Center · USDana-Farber Cancer Institute · USThe University of Queensland · AUQueensland University of Technology · AURoyal Women's Hospital · AUUniversity of Bristol · GBUniversity of California, Los Angeles · USUniversity of Cambridge · GBUniversity of Colorado Anschutz Medical Campus · US

Funding

Elucidation of the genetic mechanisms driving prostate tumorigenesis through integrative computational and functional approachesR01CA251555 · NCI · DANA-FARBER CANCER INST · PI FREEDMAN, MATTHEW L, PASANIUC, BOGDAN · 2021 to 2025
$3.4M
Functional Effects of Ovarian Cancer Risk VariantsR01CA211707 · NCI · CEDARS-SINAI MEDICAL CENTER · PI FREEDMAN, MATTHEW L, GAYTHER, SIMON ANDREW · 2017 to 2021
$3.3M
Defining the epigenetic landscape in human prostate cancerR01CA193910 · NCI · DANA-FARBER CANCER INST · PI BROWN, MYLES A, FREEDMAN, MATTHEW L · 2015 to 2019
$3.1M
Identifying causal variants and genes underlying breast cancer risk lociR01CA204954 · NCI · DANA-FARBER CANCER INST · PI FREEDMAN, MATTHEW L · 2016 to 2020
$3.0M
Medical Research Council MR/T043202/1NCI NIH HHS R01 CA193910NCI NIH HHS R01 CA204954NCI NIH HHS R01 CA211707NCI NIH HHS R01 CA251555
6 · The paper itself

Abstract

Endometriosis is associated with increased risk of epithelial ovarian cancers (EOCs). Using data from large endometriosis and EOC genome-wide association meta-analyses, we estimate the genetic correlation and evaluate the causal relationship between genetic liability to endometriosis and EOC histotypes, and identify shared susceptibility loci. We estimate a significant genetic correlation (r

Indexed as

EndometriosisNeoplasms, Glandular and EpithelialOvarian NeoplasmsCarcinoma, Ovarian EpithelialFemaleGenome-Wide Association StudyHumansendometriosisepithelial ovarian cancergenetic associationgenetic correlationgenetic riskhistotypeMendelian randomizationmeta-analysis

Identifiers

PMID35492879
PMCPMC9040176
OpenAlexW4220822308

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.