ArticleDiabetes2022
Differentiating Associations of Glycemic Traits With Atherosclerotic and Thrombotic Outcomes: Mendelian Randomization Investigation.
Article in Diabetes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Mendelian randomization studies on ischemic stroke: a field synopsis and systematic review.Journal of translational medicine · 2025Pooled it
- Polyphenol Diversity and Chemotype Variation inMolecules (Basel, Switzerland) · 2026Article
- Disentangling the relationship between glucose, insulin and brain health: A UK Biobank study.Diabetes, obesity & metabolism · 2026Article
- Diagnosis of diabetes without oral glucose tolerance test is associated with increased mortality in older adults.Scientific reports · 2025Article
- Exploring the shared genetic landscape of diabetes and cardiovascular disease: findings and future implications.Diabetologia · 2025Review
- Article
- A two-sample Mendelian randomization study explores metabolic profiling of different glycemic traits.Communications biology · 2024Article
- Mendelian randomization for cardiovascular diseases: principles and applications.European heart journal · 2023Review
- Incretins and cardiovascular disease: to the heart of type 2 diabetes?Diabetologia · 2023Review
- Article
- A Reassessment of the Causal Effects of Dysglycemia on Atherosclerotic and Thrombotic Events.Diabetes · 2022Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
We conducted a Mendelian randomization analysis to differentiate associations of four glycemic indicators with a broad range of atherosclerotic and thrombotic diseases. Independent genetic variants associated with fasting glucose (FG), 2 h glucose after an oral glucose challenge (2hGlu), fasting insulin (FI), and glycated hemoglobin (HbA1c) at the genome-wide significance threshold were used as instrumental variables. Summary-level data for 12 atherosclerotic and 4 thrombotic outcomes were obtained from large genetic consortia and the FinnGen and UK Biobank studies. Higher levels of genetically predicted glycemic traits were consistently associated with increased risk of coronary atherosclerosis-related diseases and symptoms. Genetically predicted glycemic traits except HbA1c showed positive associations with peripheral artery disease risk. Genetically predicted FI levels were positively associated with risk of ischemic stroke and chronic kidney disease. Genetically predicted FG and 2hGlu were positively associated with risk of large artery stroke. Genetically predicted 2hGlu levels showed positive associations with risk of small vessel stroke. Higher levels of genetically predicted glycemic traits were not associated with increased risk of thrombotic outcomes. Most associations for genetically predicted levels of 2hGlu and FI remained after adjustment for other glycemic traits. Increase in glycemic status appears to increase risks of coronary and peripheral artery atherosclerosis but not thrombosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.