Evidence map›Paper›PMID 35500162›Full record

ReviewReproduction in domestic animals = Zuchthygiene2022

Immunological uterine response to pig embryos before and during implantation.

Inmaculada Parrilla, Maria Antonia Gil, Cristina Cuello, Josep M Cambra, Alejandro Gonzalez-Plaza, Xiomara Lucas, Jose L Vazquez, Juan M Vazquez, Heriberto Rodriguez-Martinez, Emilio A Martinez

Open access · bronzeAbstract readReview
In one paragraph

Review in Reproduction in domestic animals = Zuchthygiene, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  6. Insights into the single-cell transcriptome characteristics of porcine endometrium with embryo loss.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  7. Article
  8. Review
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  12. Immunological uterine response to pig embryos before and during implantation.Reproduction in domestic animals = Zuchthygiene · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Inmaculada ParrillaDepartment of Medicine and Animal Surgery, Faculty of Veterinary Medicine, International Excellence Campus for Higher Education and Research "Campus Mare Nostrum", University of Murcia, Murcia, Spain.ORCID https://orcid.org/0000-0002-5121-758X
Maria Antonia GilDepartment of Medicine and Animal Surgery, Faculty of Veterinary Medicine, International Excellence Campus for Higher Education and Research "Campus Mare Nostrum", University of Murcia, Murcia, Spain.ORCID https://orcid.org/0000-0002-6955-7750
Cristina CuelloDepartment of Medicine and Animal Surgery, Faculty of Veterinary Medicine, International Excellence Campus for Higher Education and Research "Campus Mare Nostrum", University of Murcia, Murcia, Spain.ORCID https://orcid.org/0000-0002-6202-5946
Josep M CambraDepartment of Medicine and Animal Surgery, Faculty of Veterinary Medicine, International Excellence Campus for Higher Education and Research "Campus Mare Nostrum", University of Murcia, Murcia, Spain.
Alejandro Gonzalez-PlazaDepartment of Medicine and Animal Surgery, Faculty of Veterinary Medicine, International Excellence Campus for Higher Education and Research "Campus Mare Nostrum", University of Murcia, Murcia, Spain.
Xiomara LucasDepartment of Medicine and Animal Surgery, Faculty of Veterinary Medicine, International Excellence Campus for Higher Education and Research "Campus Mare Nostrum", University of Murcia, Murcia, Spain.
Jose L VazquezDepartment of Medicine and Animal Surgery, Faculty of Veterinary Medicine, International Excellence Campus for Higher Education and Research "Campus Mare Nostrum", University of Murcia, Murcia, Spain.
Juan M VazquezDepartment of Medicine and Animal Surgery, Faculty of Veterinary Medicine, International Excellence Campus for Higher Education and Research "Campus Mare Nostrum", University of Murcia, Murcia, Spain.
Heriberto Rodriguez-MartinezDepartment of Biomedical & Clinical Sciences (BKV/Obst&Gyn), Linköping University, Linköping, Sweden.
Emilio A MartinezDepartment of Medicine and Animal Surgery, Faculty of Veterinary Medicine, International Excellence Campus for Higher Education and Research "Campus Mare Nostrum", University of Murcia, Murcia, Spain.ORCID https://orcid.org/0000-0003-1260-9721
Instituto Murciano de Investigación Biosanitaria · ESLinköping University · SE

Funding

Council FORMAS 2019-00288Fundación Séneca 19892/GERM/15Ministerio de Ciencia e Innovación
6 · The paper itself

Abstract

The establishment of a successful pregnancy can only occur through a concerted functioning of the entire female reproductive system, allowing for fertilization, subsequent embryo development and implantation of the conceptus. In this context, the uterine immunological responses responsible for rejection or tolerance of the conceptus are of critical importance. The aim of the present review is to summarize our current knowledge about those cellular and molecular immunological events occurring at the uterine level during pre-implantation and implantation stages of pregnancy in the pig. Advancing our understanding of the immune mechanisms involved in the success or failure of pregnancy will provide cues to develop novel strategies augmenting endometrial receptivity, finally increasing the efficiency of assisted reproductive technologies in pigs.

Indexed as

Embryo ImplantationUterusAnimalsEmbryo, MammalianEmbryonic DevelopmentEndometriumFemalePregnancySwineallogenicembryohemiallogenicimmune tolerancepigpregnancy

Identifiers

PMID35500162
PMCPMC9790529
OpenAlexW4225289764

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.