Evidence map›Paper›PMID 35501653›Full record

ArticleBulletin of experimental biology and medicine2022

Tightly Focused Femtosecond Laser Radiation Induces DNA Double-Strand Breaks in Human Tumor Cells.

Yu A Fedotov, A D Zalessky, E I Yashkina, Yu A Zrilova, A N Osipov

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yu A FedotovN. N. Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
A D ZalesskyN. N. Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
E I YashkinaN. N. Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
Yu A ZrilovaA. I. Burnasyan Federal Medical Biophysical Center, Federal Medical-Biological Agency of Russia, Moscow, Russia.
A N OsipovN. N. Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow, Russia. andreyan.osipov@gmail.com.
Semenov Institute of Chemical Physics · RUFederal Medical-Biological Agency · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the formation of double-strand DNA breaks (DNA DSB) induced by femtosecond laser radiation in A549 human lung adenocarcinoma cells using immunocytochemical staining of the resulting tracks of a specific DSB marker protein phosphorylated ATM kinase (phospho-ATM). Additionally, colocalization of phospho-ATM tracks with γH2AX protein tracks was studied. The results of immunocytochemical analysis showed that 30 min after irradiation of cells with femtosecond pulses with energies of 1 and 2 nJ (radiation power density 2×10

Indexed as

DNA Breaks, Double-StrandedLasersCell NucleusDNA RepairHumansdouble-strand DNA breaksfemtosecond laser radiationphospho-ATMtumor cellsγH2AX

Identifiers

PMID35501653
OpenAlexW4225408299

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.