Evidence map›Paper›PMID 35501802›Full record

ReviewJournal of nanobiotechnology2022

Extracellular vesicle-mediated crosstalk between pancreatic cancer and stromal cells in the tumor microenvironment.

Ying Li, Wenjing Zhao, Yanli Wang, Haiyan Wang, Shanglong Liu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

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  17. Glioma-Derived Exosomes and Their Application as Drug Nanoparticles.International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ying LiDepartment of Blood Transfusion, the Affiliated Hospital of Qingdao University, Qingdao, China.
Wenjing ZhaoCentral Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Yanli WangDepartment of Operating Room, The Affiliated Hospital of Qingdao University, Qingdao, China.
Haiyan WangDepartment of Blood Transfusion, the Affiliated Hospital of Qingdao University, Qingdao, China.
Shanglong LiuDepartment of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China. liushanglong@qdyy.cn.ORCID http://orcid.org/0000-0002-5828-4718

Funding

Key Technology Research and Development Program of Shandong 2018GSF118088National Natural Science Foundation of China 81802888Postdoctoral Research Foundation of China 2016M592143
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) interacts closely with the tumor microenvironment (TME). The TME is remodeled by crosstalk between pancreatic cancer cells and stromal cells, and is critical for cancer progression. Extracellular vesicles (EVs), including exosomes and microvesicles, help facilitate an exchange of information both within the TME and to distant organs. EVs have also been identified as potential diagnostic biomarkers, therapeutic targets, and drug carriers for pancreatic cancer treatment. Thus, understanding the selective packaging of EVs cargo and its mechanistic impact will increase our understanding of cancer biology. In this review, we collect and analyze recent findings of the pancreatic cancer-stromal cell interactions mediated by EVs and the mechanisms involved in cancer-related immunity and chemoresistance. These studies demonstrate the vital role of EVs in pancreatic cancer reprogramming and TME remodeling. We also summarize the EVs identified as potential PDAC diagnostic biomarkers and possible therapeutic targets. This greater understanding is a promising avenue for transitioning EVs from bench to bedside.

Indexed as

Extracellular VesiclesPancreatic NeoplasmsBiomarkersHumansStromal CellsTumor MicroenvironmentBiomarkersClinical applicationsCommunicationExtracellular vesiclesPancreatic cancerTumor microenvironment

Identifiers

PMID35501802
PMCPMC9063273

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.