Evidence map›Paper›PMID 35502212›Full record

ArticleOxidative medicine and cellular longevity2022

Salivary Proteome, Inflammatory, and NETosis Biomarkers in Older Adult Practitioners and Nonpractitioners of Physical Exercise.

Valeria B Pacheco, Giulia Nery, Larissa L Fernandes, Thais V Santana, Manuel Jimenez, Leandro Borges, Elaine Hatanaka, Pedro Braga, Fernanda R Monteiro, Jônatas B Amaral and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Impact of physical activity on oral health: A systematic review.Journal of family medicine and primary care · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 3 countries.

Valeria B PachecoPost Graduate Program in Dentistry, Cruzeiro do Sul University, São Paulo 01506-000, Brazil.
Giulia NeryPost Graduate Program in Dentistry, Cruzeiro do Sul University, São Paulo 01506-000, Brazil.
Larissa L FernandesPost Graduate Program in Dentistry, Cruzeiro do Sul University, São Paulo 01506-000, Brazil.
Thais V SantanaCore Facility for Scientific Research (CEFAP-Biomass), Universidade de São Paulo, São Paulo 05508-000, Brazil.
Manuel JimenezDepartamento de Didáctica de la Educación Física y Salud, Universidad Internacional de La Rioja, Logroño 26006, Spain.ORCID https://orcid.org/0000-0002-5877-3482
Leandro BorgesInterdisciplinary Program in Health Sciences, Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, São Paulo 01506-000, Brazil.
Elaine HatanakaInterdisciplinary Program in Health Sciences, Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, São Paulo 01506-000, Brazil.
Pedro BragaFederal University of São Paulo (UNIFESP), São Paulo 04021-001, Brazil.
Fernanda R MonteiroDepartment of Otorhinolaryngology, ENT Lab, Federal University of Sao Paulo (UNIFESP), São Paulo 04021-001, Brazil.
Jônatas B AmaralDepartment of Otorhinolaryngology, ENT Lab, Federal University of Sao Paulo (UNIFESP), São Paulo 04021-001, Brazil.
Luana S AlvesDepartment of Restorative Dentistry, School of Dentistry, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.
André L L BachiDepartment of Otorhinolaryngology, ENT Lab, Federal University of Sao Paulo (UNIFESP), São Paulo 04021-001, Brazil.ORCID https://orcid.org/0000-0001-8266-1416
Sérgio Gomes da SilvaFederal University of São Paulo (UNIFESP), São Paulo 04021-001, Brazil.
Alexander BirbrairDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil.
Débora HellerPost Graduate Program in Dentistry, Cruzeiro do Sul University, São Paulo 01506-000, Brazil.ORCID https://orcid.org/0000-0002-5084-8179
Universidade Cruzeiro do Sul · BRUniversidade Federal de São Paulo · BRSupport group for adolescents and children with cancer · BRThe University of Texas Health Science Center at San Antonio · USUniversidade de Santo Amaro · BRUniversidade de São Paulo · BRUniversidade Federal de Minas Gerais · BRUniversidade Federal de Santa Maria · BRUniversidad Internacional De La Rioja · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since aging has been associated with increased production of inflammatory biomarkers, the ability to monitor older adults repeatedly is highly desirable, and saliva is an interesting biofluid for the search of biomarkers, as it is easily accessible in a noninvasive manner. However, given the incipient knowledge of salivary biomarkers in aging and its relationship to physical exercise, the present study is aimed at evaluating the protein expression and the levels of inflammatory and NETosis biomarkers in the saliva of practitioners (PE) and nonpractitioners (NPE) of physical exercise older adults. Six (6) practitioner and 4 nonpractitioner older adults were enrolled in this study. Unstimulated whole saliva was collected for analysis of the proteome by label-free mass spectrometry, as well as of the inflammatory status by evaluation of C-reactive protein (CRP), vascular endothelial growth factor (VEGF), and cytokines (TNF-

Indexed as

ProteomeVascular Endothelial Growth Factor AAgedBiomarkersC-Reactive ProteinExerciseHumansBiomarkersC-Reactive ProteinProteomeVascular Endothelial Growth Factor A

Identifiers

PMID35502212
PMCPMC9056209
OpenAlexW4224281970

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.