ArticlePediatrics2022
Cardiovascular Risk Factors and Target Organ Damage in Adolescents: The SHIP AHOY Study.
Article in Pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Isolated Nocturnal Hypertension and Target Organ Damage: A SHIP-AHOY Ancillary Study.Research square · 2026Article
- Vascular and blood pressure alterations in children two years after multisystem inflammatory syndrome.Scientific reports · 2026Article
- Tackling the epidemic of obesity and hypertension in children and young people.Current opinion in nephrology and hypertension · 2026Review
- Childhood Obesity: A Multisystem Challenge Linking Hypertension, NAFLD, and Sleep Apnea.Medical sciences (Basel, Switzerland) · 2026Review
- The "pressure" of being an adolescent in the West Bank, Palestine: prevalence of prehypertension and hypertension.Frontiers in public health · 2025Article
- The Study of the Epidemiology of Pediatric Hypertension Registry (SUPERHERO): rationale and methods.American journal of epidemiology · 2024Article
- Systolic Blood Pressure, Cardiovascular Health, and Neurocognition in Adolescents.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Trends in cardiovascular risk factor prevalence, treatment, and control among US adolescents aged 12 to 19 years, 2001 to March 2020.BMC medicine · 2024Article
- The Effect of "Unclassified" Blood Pressure Phenotypes on Left Ventricular Hypertrophy.Turkish archives of pediatrics · 2024Article
- Superiority of a Representative MRI Flow Waveform over Doppler Ultrasound for Aortic Wave Reflection Assessment in Children and Adolescents With/Without a History of Heart Disease.Annals of biomedical engineering · 2023Article
- Blood Pressure in Children in the 21st Century: What Do We Know and Where Do We Go From Here?Hypertension (Dallas, Tex. : 1979) · 2023Review
- Joint statement for assessing and managing high blood pressure in children and adolescents: Chapter 1. How to correctly measure blood pressure in children and adolescents.Frontiers in pediatrics · 2023Article
- Prevalence of and Factors Associated With High Blood Pressure Among Adolescents in India.JAMA network open · 2022Article
- The enigma of primary hypertension in childhood.Frontiers in cardiovascular medicine · 2022Review
Corrections and comments
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Authors and funding
17 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundDevelopment of cardiovascular disease in adults has been directly linked to an adverse metabolic phenotype. While there is evidence that development of these risk factors in childhood persists into adulthood and the development of cardiovascular disease, less is known about whether these risk factors are associated with target organ damage during adolescence.
methodsWe collected data from 379 adolescents (mean age 15.5, 60% male) with blood pressure between the 75th and 95th percentile to determine if there is a metabolic phenotype that predicts cardiovascular changes (left ventricular mass, systolic and diastolic function, pulse wave velocity, and renal function). We determined the number of risk factors for cardiovascular disease (hypertension, dyslipidemia, obesity, and insulin resistance) present in each participant. Generalized linear models were constructed to determine if the number of cardiovascular risk factors (CVRFs) were associated with measures of target organ damage.
resultsThe number of CVRFs present were associated with statistically significant differences in increased left ventricular mass index, increased pulse wave velocity, decreased peak longitudinal strain, urine albumin to creatine ratio and echocardiographic parameters of diastolic dysfunction. Generalized linear models showed that dyslipidemia and insulin resistance were independently associated with markers of diastolic dysfunction (P ≤ .05) while increased blood pressure was associated with all makers of target organ damage (P ≤ .03).
conclusionsThese data suggest the of the number of CVRFs present is independently associated with early changes in markers of target organ damage during adolescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.