Evidence map›Paper›PMID 35503096›Full record

ArticleeLife2022

Discovery and functional assessment of a novel adipocyte population driven by intracellular Wnt/β-catenin signaling in mammals.

Zhi Liu, Tian Chen, Sicheng Zhang, Tianfang Yang, Yun Gong, Hong-Wen Deng, Ding Bai, Weidong Tian, YiPing Chen

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Navigating Lipodystrophy: Insights from Laminopathies and Beyond.International journal of molecular sciences · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Zhi Liu *Department of Cell and Molecular Biology, Tulane University, New Orleans, United States.ORCID 0000-0001-6183-498X
Tian Chen *Department of Cell and Molecular Biology, Tulane University, New Orleans, United States.
Sicheng ZhangDepartment of Cell and Molecular Biology, Tulane University, New Orleans, United States.
Tianfang YangDepartment of Cell and Molecular Biology, Tulane University, New Orleans, United States.
Yun GongTulane Center of Biomedical Informatics and Genomic, Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, United States.
Hong-Wen DengTulane Center of Biomedical Informatics and Genomic, Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, United States.
Ding BaiState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Weidong TianState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
YiPing ChenDepartment of Cell and Molecular Biology, Tulane University, New Orleans, United States.ORCID 0000-0002-8628-7713
Tulane University · USSichuan University · CN

Funding

Characterization and functional assessment of a novel population of Wnt/beta-catenin driven adopocytes.R01DK128907 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI CHEN, YIPING, WANG, QIONG ANNABEL · 2021 to 2024
$2.0M
NIDDK NIH HHS R01 DK128907
6 · The paper itself

Abstract

Wnt/β-catenin signaling has been well established as a potent inhibitor of adipogenesis. Here, we identified a population of adipocytes that exhibit persistent activity of Wnt/β-catenin signaling, as revealed by the Tcf/Lef-GFP reporter allele, in embryonic and adult mouse fat depots, named as Wnt

Indexed as

Adipocytesbeta CateninAdipogenesisAnimalsGlucoseMammalsMiceWnt Signaling Pathwaybeta CateninGlucoseadipocyteAKT/mTOR signalingbeigingcell biologyglucose homeostasismouseβ-catenin signaling

Identifiers

PMID35503096
PMCPMC9064292
OpenAlexW4225320188

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.