ArticleNature communications2022
Multivariate genome-wide association study on tissue-sensitive diffusion metrics highlights pathways that shape the human brain.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Multiancestry and Multitrait GWAS Meta-Analysis on Schizophrenia With a Sample of 322,321 Unveils Genetic Links to Chronic Lung Diseases.Genes, brain, and behavior · 2026Pooled it
- Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.Translational psychiatry · 2025Pooled it
- The genetics of fibromyalgia and its relationships to psychiatric and medical traits.Nature communications · 2026Article
- Human genetics across levels of biological organization.Nature reviews. Genetics · 2026Review
- Exploration of Genetic Overlap of Brain Phenotypes With Schizophrenia: Different Methods Provide Complementary Insights.Schizophrenia bulletin · 2026Article
- Genetic architecture of white matter microstructure captured by unsupervised deep representation learning of fractional anisotropy maps.Nature communications · 2026Article
- A decade of discovery: Leveraging genomic data in the ABCD study to illuminate adolescent neurodevelopment.Developmental cognitive neuroscience · 2026Review
- Learning dynamics of unsupervised deep learning reveal epoch-specific genetic architectures of brain morphology.bioRxiv : the preprint server for biology · 2026Article
- Computation and resource efficient genome-wide association analysis for large-scale imaging studies.Nature communications · 2026Article
- Genetic and epigenetic analysis of plasma glial fibrillary acidic protein (GFAP) levels in PTSD.Molecular psychiatry · 2026Article
- Multivariate patterns linking brain microstructure to temperament and behavior in adolescent eating disorders.Molecular psychiatry · 2025Article
- Multi-omics integration reveals Chr1 associated QTL mediating backfat thickness in pigs.Journal of animal science and biotechnology · 2025Article
- Unveiling genetic architecture of white matter microstructure through unsupervised deep representation learning of fractional anisotropy maps.Research square · 2025Article
- The cellular associates of late life changes in white matter microstructure.bioRxiv : the preprint server for biology · 2025Article
- Mapping Structural Neuroimaging Trajectories in Bipolar Disorder: Neurobiological and Clinical Implications.Biological psychiatry · 2025Review
- Dietary Factors Affect Brain Iron Accumulation and Parkinson's Disease Risk.medRxiv : the preprint server for health sciences · 2025Article
- Whole genome sequence association analysis of brain structural volume measures in the NHLBI TOPMed Program highlights novel loci in diverse participants.medRxiv : the preprint server for health sciences · 2025Article
- Beyond volume: Unraveling the genetics of human brain geometry.Science advances · 2025Article
- Enhanced insights into the genetic architecture of 3D cranial vault shape using pleiotropy-informed GWAS.Communications biology · 2025Article
- Multivariate patterns linking brain microstructure to temperament and behavior in adolescent eating disorders.medRxiv : the preprint server for health sciences · 2024Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 3 countries.
Funding
Abstract
The molecular determinants of tissue composition of the human brain remain largely unknown. Recent genome-wide association studies (GWAS) on this topic have had limited success due to methodological constraints. Here, we apply advanced whole-brain analyses on multi-shell diffusion imaging data and multivariate GWAS to two large scale imaging genetic datasets (UK Biobank and the Adolescent Brain Cognitive Development study) to identify and validate genetic association signals. We discover 503 unique genetic loci that have impact on multiple regions of human brain. Among them, more than 79% are validated in either of two large-scale independent imaging datasets. Key molecular pathways involved in axonal growth, astrocyte-mediated neuroinflammation, and synaptogenesis during development are found to significantly impact the measured variations in tissue-specific imaging features. Our results shed new light on the biological determinants of brain tissue composition and their potential overlap with the genetic basis of neuropsychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.