Evidence map›Paper›PMID 35506099›Full record

ArticlePulmonary circulation2022

Pulsatile pulmonary artery pressure in a large animal model of chronic thromboembolic pulmonary hypertension: Similarities and differences with human data.

David Boulate, Fanny Loisel, Mathieu Coblence, Bastien Provost, Alban Todesco, Benoit Decante, Antoine Beurnier, Philippe Herve, Frédéric Perros, Marc Humbert and 3 more

Open access · goldAbstract read
In one paragraph

Article in Pulmonary circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. [Application of Animal Models in Research on Hypoxia-Related Diseases].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

David BoulateHôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.
Fanny LoiselHôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.
Mathieu CoblenceHôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.
Bastien ProvostHôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.
Alban TodescoHôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.
Benoit DecanteHôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.
Antoine BeurnierHôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.
Philippe HerveHôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.
Frédéric PerrosHôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.
Marc HumbertHôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.
Elie FadelHôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.
Olaf MercierHôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.
Denis ChemlaHôpital Marie Lannelongue INSERM UMR_S 999 Le Plessis Robinson France.
Hôpital Marie Lannelongue · FRInserm · FRBicêtre Hospital · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A striking feature of the human pulmonary circulation is that mean (mPAP) and systolic (sPAP) pulmonary artery pressures (PAPs) are strongly related and, thus, are essentially redundant. According to the empirical formula documented under normotensive and hypertensive conditions (mPAP = 0.61 sPAP + 2 mmHg), sPAP matches ~160%mPAP on average. This attests to the high pulsatility of PAP, as also witnessed by the near equality of PA pulse pressure and mPAP. Our prospective study tested if pressure redundancy and high pulsatility also apply in a piglet model of chronic thromboembolic pulmonary hypertension (CTEPH). At baseline (Week-0, W0), Sham (

Indexed as

animal modelspathophysiologypulmonary hypertension experimentalright ventricle function and dysfunction

Identifiers

PMID35506099
PMCPMC9052967
OpenAlexW4200625102

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.