Evidence map›Paper›PMID 35506387›Full record

ReviewStroke2022

Impact of Exercise on Cerebrovascular Physiology and Risk of Stroke.

Justin A Edward, William K Cornwell

Open access · bronzeAbstract readReview
In one paragraph

Review in Stroke, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 5 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Combined cardiorespiratory and resistance training for people with stroke.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Resistance training for people with stroke.The Cochrane database of systematic reviews · 2025
    Pooled it
  3. Pooled it
  4. Guideline
  5. Pooled it
  6. Observational
  7. Article
  8. Review
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  12. Review
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  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Justin A EdwardDepartment of Medicine-Cardiology (J.A.E., W.K.C.), University of Colorado Anschutz Medical Campus, Aurora.ORCID 0000-0002-6939-4963
William K CornwellDepartment of Medicine-Cardiology (J.A.E., W.K.C.), University of Colorado Anschutz Medical Campus, Aurora.ORCID 0000-0002-0863-1187
University of Colorado Anschutz Medical Campus · US

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Effect of Mechanical Circulatory Support on Exercise Capacity in Heart FailureK23HL132048 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI CORNWELL, WILLIAM · 2016 to 2020
$819k
NCATS NIH HHS UL1 TR002535NHLBI NIH HHS K23 HL132048
6 · The paper itself

Abstract

Ischemic heart disease and stroke are the number 1 and number 2 causes of death worldwide, respectively. A lifelong commitment to exercise reduces the risk of these adverse events and is also associated with several cardiometabolic improvements, including reductions in blood pressure, cholesterol, and inflammatory markers, as well as improved glucose control. Routine exercise also reduces the risk of developing comorbidities that increase the risk of cardiovascular or cerebrovascular disease. While the benefits of a lifelong commitment to exercise are well documented, there is a complex interaction between exercise and stroke risk, such that the risk of ischemic or hemorrhagic stroke may increase acutely during or immediately following exercise. In this article, we discuss the physiological responses to different types of exercise, as well as the determinants of resting and exertional cerebrovascular perfusion, and explore the complex interaction between atrial fibrillation, exercise, and stroke risk. Finally, we highlight the increased risk of stroke during different types of exercise, as well as factors that may alleviate this risk.

Indexed as

Atrial FibrillationStrokeBlood PressureExerciseHumansRisk Factorsatrial fibrillationblood glucoseblood pressurecause of deathexercisehemorrhagic strokeischemic stroke

Identifiers

PMID35506387
PMCPMC9246957
OpenAlexW4229014963

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.