ArticleMolecular systems biology2022
Diauxic lags explain unexpected coexistence in multi-resource environments.
Article in Molecular systems biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Cross-feeding enables robust coexistence between four bacterial species.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Increased nutrient diversity can induce loss of microbial diversity through enhanced resource uptake.Nature ecology & evolution · 2026Article
- Minimizing co-growth as a broad predictor of community robustness.bioRxiv : the preprint server for biology · 2026Article
- Population dynamics of generalist and specialist strategies under feast-famine cycles.PLoS computational biology · 2026Article
- Time Series Data Mining for Linking the Shape of Bacterial Growth Curves to Biological Functions.Computational and structural biotechnology journal · 2026Article
- Translating microbial kinetics into quantitative responses and testable hypotheses using Kinbiont.Nature communications · 2025Article
- Coarse-grained model of serial dilution dynamics in synthetic human gut microbiome.PLoS computational biology · 2025Article
- Dynamic coexistence driven by physiological transitions in microbial communities.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Phage-mediated intercellular CRISPRi for biocomputation in bacterial consortia.Nucleic acids research · 2025Article
- Ecosystem stability relies on diversity difference between trophic levels.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Evolution and stability of complex microbial communities driven by trade-offs.Molecular systems biology · 2024Review
- Shaping of microbial phenotypes by trade-offs.Nature communications · 2024Review
- Biodiversity is enhanced by sequential resource utilization and environmental fluctuations via emergent temporal niches.PLoS computational biology · 2024Article
- Resource competition predicts assembly of gut bacterial communities in vitro.Nature microbiology · 2024Article
- Article
- Low-level resource partitioning supports coexistence among functionally redundant bacteria during successional dynamics.The ISME journal · 2024Article
- Searching for Principles of Microbial Ecology Across Levels of Biological Organization.Integrative and comparative biology · 2023Article
- Inducible CRISPR-targeted "knockdown" of human gutProceedings of the National Academy of Sciences of the United States of America · 2023Article
- The Architecture of Metabolic Networks Constrains the Evolution of Microbial Resource Hierarchies.Molecular biology and evolution · 2023Article
- Resource competition can explain simplicity in microbial community assembly.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
How the coexistence of species is affected by the presence of multiple resources is a major question in microbial ecology. We experimentally demonstrate that differences in diauxic lags, which occur as species deplete their own environments and adapt their metabolisms, allow slow-growing microbes to stably coexist with faster-growing species in multi-resource environments despite being excluded in single-resource environments. In our focal example, an Acinetobacter species (Aci2) competitively excludes Pseudomonas aurantiaca (Pa) on alanine and on glutamate. However, they coexist on the combination of both resources. Experiments reveal that Aci2 grows faster but Pa has shorter diauxic lags. We establish a tradeoff between Aci2's fast growth and Pa's short lags as their mechanism for coexistence. We model this tradeoff to accurately predict how environmental changes affect community composition. We extend our work by surveying a large set of competitions and observe coexistence nearly four times as frequently when the slow-grower is the fast-switcher. Our work illustrates a simple mechanism, based entirely on supplied-resource growth dynamics, for the emergence of multi-resource coexistence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.