Evidence map›Paper›PMID 35508662›Full record

ArticleNature2022

Transcriptional coupling of distant regulatory genes in living embryos.

Michal Levo, João Raimundo, Xin Yang Bing, Zachary Sisco, Philippe J Batut, Sergey Ryabichko, Thomas Gregor, Michael S Levine

Open access · greenAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers.

0numbers the graph read from it
0cells of the map it votes in
125citing papers in PubMed
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

125 citing papers in PubMed, 188 citations in OpenAlex.

  1. Article
  2. Article
  3. Transcription and Three-Dimensional Genome Organization: Cause, Consequence, or Coordination?BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  4. Article
  5. Current Challenges of Transcription Compartmentalization Research.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  6. Developmental expression of the skeletal muscle determination gene,bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Maternal IntS11 primes embryonic totipotency by organizing early zygotic transcription initiation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  15. Article
  16. Facilitators may represent a new class of regulatory elements.Current opinion in genetics & development · 2026
    Review
  17. Article
  18. Article
  19. Article
  20. Article

65 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Michal Levo *Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-6647-8221
João Raimundo *Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-8976-1898
Xin Yang BingLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Zachary SiscoLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Philippe J BatutLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0003-4250-0663
Sergey RyabichkoLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0003-1309-9436
Thomas GregorLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA. tg2@princeton.edu.ORCID http://orcid.org/0000-0001-9460-139X
Michael S LevineLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA. msl2@princeton.edu.ORCID http://orcid.org/0000-0001-7629-0081
Princeton University · USInstitut Pasteur · FR

Funding

Visualization of gene activity in the Drosophila embryoR35GM118147 · NIGMS · PRINCETON UNIVERSITY · PI Michael Steven Levine · 2016 to 2026
$6.7M
The Biophysical and Molecular Mechanisms of Reliability in DevelopmentR01GM097275 · NIGMS · PRINCETON UNIVERSITY · PI GREGOR, THOMAS · 2011 to 2024
$4.9M
Control of the 4D chromatin landscape underlying gene activity during developmentU01DK127429 · NIDDK · PRINCETON UNIVERSITY · PI GREGOR, THOMAS, LEVINE, MICHAEL STEVEN · 2020 to 2024
$3.2M
Imaging chromosome dynamics and measuring its impact on transcriptional activityU01EB021239 · NIBIB · PRINCETON UNIVERSITY · PI GREGOR, THOMAS, LEVINE, MICHAEL STEVEN · 2015 to 2017
$1.1M
Imaging chromosome dynamics and measuring its impact on transcriptional activityU01DA047730 · NIDA · PRINCETON UNIVERSITY · PI GREGOR, THOMAS, LEVINE, MICHAEL STEVEN · 2018 to 2019
$740k
NIBIB NIH HHS U01 EB021239NIDA NIH HHS U01 DA047730NIDDK NIH HHS U01 DK127429NIGMS NIH HHS R01 GM097275NIGMS NIH HHS R35 GM118147
6 · The paper itself

Abstract

The prevailing view of metazoan gene regulation is that individual genes are independently regulated by their own dedicated sets of transcriptional enhancers. Past studies have reported long-range gene-gene associations

Indexed as

Enhancer Elements, GeneticGene Expression Regulation, DevelopmentalTranscription, GeneticAnimalsDrosophilaEmbryonic DevelopmentGenes, RegulatorGenomePromoter Regions, GeneticSingle-Cell Analysis

Identifiers

PMID35508662
PMCPMC9886134
OpenAlexW4229004838

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.