Evidence map›Paper›PMID 35508803›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

The Protective Effects of Osteocyte-Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with Aging.

Ya-Ling Jiang, Zhen-Xing Wang, Xi-Xi Liu, Mei-Dan Wan, Yi-Wei Liu, Bin Jiao, Xin-Xin Liao, Zhong-Wei Luo, Yi-Yi Wang, Chun-Gu Hong and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 2 institutions in 1 country.

Ya-Ling JiangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Zhen-Xing WangDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.ORCID 0000-0003-1575-1459
Xi-Xi LiuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Mei-Dan WanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Yi-Wei LiuDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Bin JiaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Xin-Xin LiaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Zhong-Wei LuoDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Yi-Yi WangDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Chun-Gu HongDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Yi-Juan TanDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Ling WengDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Ya-Fang ZhouDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Shan-Shan RaoDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Jia CaoDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Zheng-Zhao LiuDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Teng-Fei WanDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Yuan ZhuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Hui XieDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.ORCID 0000-0002-8526-2637
Lu ShenDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.ORCID 0000-0002-3393-8578
Central South University · CNHunan International Economics University · CN

Funding

China Postdoctoral Science Foundation 2017M612596China Postdoctoral Science Foundation 2019T120717Hunan Innovative Province Construction Project 2019SK2335Hunan Province Natural Science Foundation of China 2020JJ4914Innovation Driven Project of Central South University 2018CX029Innovation Driven Project of Central South University 2019CX014National Key Research and Development Program of China 2020YFC2008500National Natural Science Foundation of China 81801395National Natural Science Foundation of China 81871822National Natural Science Foundation of China 81901171National Natural Science Foundation of China 81971029National Natural Science Foundation of China 81974127National Natural Science Foundation of China 82071216National Natural Science Foundation of China 82072504Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences 2019-RC-HL-024Science and Technology Innovation Program of Hunan Province 2020RC4008Science and Technology Plan Project of Hunan Province 2017XK2039Science and Technology Plan Project of Hunan Province 2018RS3029
6 · The paper itself

Abstract

Both Alzheimer's disease (AD) and osteoporosis (OP) are common age-associated degenerative diseases and are strongly correlated with clinical epidemiology. However, there is a lack of clear pathological relationship between the brain and bone in the current understanding. Here, it is found that young osteocyte, the most abundant cells in bone, secretes extracellular vesicles (OCY

Indexed as

Alzheimer DiseaseExtracellular VesiclesAgingAnimalsMiceOsteocytesProteomicsagingAlzheimer's diseaseextracellular vesiclesosteocyteosteoporosis

Identifiers

PMID35508803
PMCPMC9189667
OpenAlexW4229036066

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.