Evidence map›Paper›PMID 35509068›Full record

ArticleRespiratory research2022

The role of retinoid-related orphan receptor-α in cigarette smoke-induced autophagic response.

Hak-Su Kim, Chang Hyeok An, Danielle Teller, Su-Jin Moon, Gi Won Hwang, Jin Woo Song

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Hak-Su KimVeterans Health Service Medical Center, Veterans Medical Research Institute, Seoul, Republic of Korea.
Chang Hyeok AnDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, USA.
Danielle TellerDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, USA.
Su-Jin MoonDepartment of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea.
Gi Won HwangDepartment of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea.
Jin Woo SongDepartment of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea. jwsongasan@gmail.com.ORCID http://orcid.org/0000-0001-5121-3522
Ulsan College · KRBrigham and Women's Hospital · US

Funding

National Research Foundation of Korea NRF-2016R1A2B4016318National Research Foundation of Korea NRF-2019R1A2C2008541
6 · The paper itself

Abstract

backgroundRetinoid-related orphan receptor-α (RORα) and autophagy dysregulation are involved in the pathophysiology of chronic obstructive pulmonary disease (COPD), but little is known regarding their association. We investigated the role of RORα in COPD-related autophagy.

methodsThe lung tissues and cells from a mouse model were analyzed for autophagy markers by using western blot analysis and transmission electron microscopy.

resultsCigarette smoke increased the LC3-II level and decreased the p62 level in whole lung homogenates of a chronic cigarette smoking mouse model. Although cigarette smoke did not affect the levels of p62 in Staggerer mutant mice (RORα

conclusionsOur findings suggest that RORα promotes autophagy and contributes to COPD pathogenesis via regulation of the RORα-p53-DRAM pathway.

Indexed as

Cigarette SmokingPulmonary Disease, Chronic ObstructiveAnimalsAutophagyMiceNicotianaNuclear Receptor Subfamily 1, Group F, Member 1Tumor Suppressor Protein p53Nuclear Receptor Subfamily 1, Group F, Member 1Tumor Suppressor Protein p53AutophagyChronic obstructive pulmonary diseaseDamage-regulated autophagy modulatorp53Retinoid-related orphan receptor-α

Identifiers

PMID35509068
PMCPMC9066967
OpenAlexW4225380006

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.