Evidence mapPaperPMID 35509178Full record

Trial reportRenal failure2022

A risk prediction model for contrast-induced nephropathy associated with gadolinium-based contrast agents.

Huanhuan Zheng, Guolang Wang, Qianqian Cao, Wenkai Ren, Lingyuan Xu, Shuangshan Bu

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Renal failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Huanhuan ZhengDepartment of Nephrology, Affiliated Dongyang Hospital of Wenzhou Medical University, Zhejiang, China.
Guolang WangDepartment of Vascular Surgery, Affiliated Dongyang Hospital of Wenzhou Medical University, Zhejiang, China.
Qianqian CaoDepartment of Nephrology, Affiliated Dongyang Hospital of Wenzhou Medical University, Zhejiang, China.
Wenkai RenDepartment of Nephrology, Affiliated Dongyang Hospital of Wenzhou Medical University, Zhejiang, China.ORCID 0000-0001-5856-7876
Lingyuan XuDepartment of Nephrology, Affiliated Dongyang Hospital of Wenzhou Medical University, Zhejiang, China.
Shuangshan BuDepartment of Nephrology, Affiliated Dongyang Hospital of Wenzhou Medical University, Zhejiang, China.
Wenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis is the first study to explore the risk factors for nephropathy caused by gadolinium-based contrast agents and establish a prediction model to identify high-risk patients.

methodsA total of 1404 patients who received gadolinium-based contrast agents in our hospital were included. The participants were randomly assigned in a 7:3 ratio to the modeling and validation groups. The modeling group was divided into a contrast-induced nephropathy group and a non-contrast-induced nephropathy group. The clinical characteristics before the use of contrast agents were compared between the two groups. The risk factors for contrast-induced nephropathy were analyzed by logistic regression. A nomogram that could predict the incidence of contrast-induced nephropathy was plotted. The validation group was used to verify the predictive model.

resultsThe incidence of contrast-induced nephropathy caused by gadolinium-based contrast agents was 3.92% (55/1404). The logistic stepwise regression analysis showed that sex, systolic pressure (SBP), absolute neutrophil count, albumin, fasting blood glucose level, and furosemide use were significant predictors of contrast-induced nephropathy caused by gadolinium-based contrast agents. The above predictors were then included in the nomogram construction. The area under the receiver operating characteristic (ROC) curve was 0.82 (

conclusionSex, SBP, absolute neutrophil count, albumin, fasting blood glucose levels, and furosemide use are significant predictors of contrast-induced nephropathy caused by gadolinium-based contrast agents. Therefore, the incidence of contrast-induced nephropathy may be estimated by the prediction model established in this study before the use of contrast agents.

Indexed as

Contrast MediaKidney DiseasesAlbuminsBlood GlucoseFemaleFurosemideGadoliniumHumansMaleRetrospective StudiesRisk FactorsROC CurveAlbuminsBlood GlucoseContrast MediaFurosemideGadoliniumContrast-induced nephropathygadolinium-based contrast agentnephrotoxicityprediction model

Identifiers

PMID35509178
PMCPMC9090414
OpenAlexW4229016830

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.