Evidence mapPaperPMID 35512975Full record

ReviewFertility and sterility2022

Subclinical cardiovascular disease and polycystic ovary syndrome.

Joanne Michelle D Gomez, Katherine VanHise, Nina Stachenfeld, Jessica L Chan, Noel Bairey Merz, Chrisandra Shufelt

Open access · greenAbstract readReview
In one paragraph

Review in Fertility and sterility, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Polycystic Ovary Syndrome Revisited: Novel Insights and Updates.International journal of medical sciences · 2026
    Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Cardiovascular contributions to dementia: Examining sex differences and female-specific factors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  17. Article
  18. Polycystic ovary syndrome as a metabolic disease.Nature reviews. Endocrinology · 2025
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Joanne Michelle D GomezBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, California.
Katherine VanHiseDepartment of Obstetrics and Gynecology, Cedars Sinai Medical Center, Los Angeles, California.
Nina StachenfeldDepartment of Obstetrics and Gynecology, Yale School of Medicine, New Haven, Connecticut.
Jessica L ChanDepartment of Obstetrics and Gynecology, Cedars Sinai Medical Center, Los Angeles, California; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Cedars Sinai Medical Center, Los Angeles, California.
Noel Bairey MerzBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, California.
Chrisandra ShufeltBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, California. Electronic address: chrisandra.shufelt@cshs.org.
Cedars-Sinai Medical Center · USYale University · US

Funding

NICHD NIH HHS R01 HD106096
6 · The paper itself

Abstract

Polycystic ovary syndrome (PCOS) impacts approximately 6%-10% of women worldwide, with hallmark features of hyperandrogenism, irregular menses, infertility, and polycystic appearing ovaries on ultrasound. In addition, PCOS is associated with several endocrine and metabolic disorders, including obesity, insulin resistance and diabetes mellitus, hypertension, dyslipidemia and metabolic syndrome, which all increase the risk for subclinical cardiovascular disease (CVD), the presence of altered vascular endothelium without overt CVD. In this review, we summarize the most recent literature regarding subclinical CVD in women with PCOS, including markers such as flow-mediated dilation, arterial stiffness, coronary artery calcium scores, carotid intima-media thickness and visceral and epicardial fat.

Indexed as

Cardiovascular DiseasesHyperandrogenismInsulin ResistancePolycystic Ovary SyndromeCarotid Intima-Media ThicknessFemaleHumansRisk FactorsEndothelial dysfunctionPCOSsubclinical cardiovascular disease

Identifiers

PMID35512975
PMCPMC10322116
OpenAlexW4229032133

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.