ArticleFrontiers in physiology2022
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon
Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Changes in circulating bile acid levels during cold exposure are associated with brown adipose tissue in humans: a secondary analysis from the ACTIBATE study.Journal of physiology and biochemistry · 2026Trial
- Climate Change-Mediated Temperature Extremes: Effects on the Immune System and Associations with Immune-Related Diseases.Clinical reviews in allergy & immunology · 2026Review
- E4BP4 interacts with PERK to form a feedback loop mediating cold-induced female reproductive disorders.Cell stress & chaperones · 2026Article
- Article
- Peripheral skin temperature during hospitalization and allergic disorders in non-NICU neonates >35 weeks.iScience · 2026Article
- Cold environment is associated with worse outcomes in ischemic stroke patients and the underlying gut microbial mechanism.BMC microbiology · 2026Article
- Trends and seasonal variation in the incidence and prevalence of irritable bowel syndrome in Korea: a multicenter OMOP CDM study.Frontiers in public health · 2026Article
- Article
- Association between extreme temperature events and multimorbidity among older adults: evidence from the CHARLS.BMC medicine · 2025Article
- Comparative evaluation of three traditional herbal formulas on gastrointestinal motility in a mouse model of cold stress-induced dyspepsia.World journal of gastroenterology · 2025Article
- Cimifugin improves intestinal barrier dysfunction by upregulating SIRT1 to regulate the NRF2/HO-1 signaling pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Effects of cold environment exposure on female reproductive health and its regulatory mechanisms.Frontiers in genetics · 2025Article
- Therapeutic Potential ofInternational journal of molecular sciences · 2024Article
- The Impact of Climate Change on Immunity and Gut Microbiota in the Development of Disease.Diseases (Basel, Switzerland) · 2024Review
- Ovarian PERK/NRF2/CX43/StAR/progesterone pathway activation mediates female reproductive dysfunction induced by cold exposure.Scientific reports · 2024Article
- Effect of chronic cold stress on gut microbial diversity, intestinal inflammation and pyroptosis in mice.Journal of physiology and biochemistry · 2024Article
- SIRT1 inhibits apoptosis of human lens epithelial cells through suppressing endoplasmic reticulum stressInternational journal of ophthalmology · 2024Article
- CD4Antioxidants & redox signaling · 2023Review
- [Cold stress reduces lifespan and mobility ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ambient air temperature is a key factor affecting human health. Long-term exposure to a cold environment can cause various diseases, while the impact on the intestine, the organ which has the largest contact area with the external environment, cannot be ignored. In this study, we investigated the effect of chronic cold exposure on the colon and its preliminary mechanism of action. Mice were exposed to 4°C for 3 hours a day for 10 days. We found that cold exposure damaged the morphology and structure of the colon, destroyed the tight junctions of the colonic epithelial tissue, and promoted inflammation of the colon. At the same time, cold exposure also activated the unfolded protein response (UPR) in the colon and promoted apoptosis in intestinal epithelial cells. Chronic cold exposure induced oxidative stress
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.