Evidence map›Paper›PMID 35524813›Full record

ArticleCell and tissue research2022

Extracellular vesicles derived from human bone marrow mesenchymal stem cells protect rats against acute myocardial infarction-induced heart failure.

Liying Xuan, Danni Fu, Dong Zhen, Chengxi Wei, Dongsong Bai, Lijun Yu, Guohua Gong

Abstract read
PubMed Publisher
In one paragraph

Article in Cell and tissue research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

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  8. Extracellular vesicle therapeutics for cardiac repair.Journal of molecular and cellular cardiology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Liying XuanMedicinal Chemistry and Pharmacology Institute, Inner Mongolia University for The Nationalities, No. 1742, Holin River Street, Tongliao, 028002, Inner Mongolia, People's Republic of China.
Danni FuMedicinal Chemistry and Pharmacology Institute, Inner Mongolia University for The Nationalities, No. 1742, Holin River Street, Tongliao, 028002, Inner Mongolia, People's Republic of China.
Dong ZhenMedicinal Chemistry and Pharmacology Institute, Inner Mongolia University for The Nationalities, No. 1742, Holin River Street, Tongliao, 028002, Inner Mongolia, People's Republic of China.
Chengxi WeiMedicinal Chemistry and Pharmacology Institute, Inner Mongolia University for The Nationalities, No. 1742, Holin River Street, Tongliao, 028002, Inner Mongolia, People's Republic of China.
Dongsong BaiMedicinal Chemistry and Pharmacology Institute, Inner Mongolia University for The Nationalities, No. 1742, Holin River Street, Tongliao, 028002, Inner Mongolia, People's Republic of China.
Lijun YuMedicinal Chemistry and Pharmacology Institute, Inner Mongolia University for The Nationalities, No. 1742, Holin River Street, Tongliao, 028002, Inner Mongolia, People's Republic of China.
Guohua GongMedicinal Chemistry and Pharmacology Institute, Inner Mongolia University for The Nationalities, No. 1742, Holin River Street, Tongliao, 028002, Inner Mongolia, People's Republic of China. gonggh1012@163.com.ORCID http://orcid.org/0000-0003-0453-3675
Inner Mongolia University for Nationalities · CN

Funding

National Natural Science Foundation of China 81860769The Inner Mongolia Health and Family Planning Foundation (201702114) and The Inner Mongolia Natural Science Foundation 2020MS08031The Inner Mongolia University for the Nationalites Science Foundation NMDYB1759The Outstanding Youth Project of Inner Mongolia Natural Science Foundation 2018JQ01Young Innovative and Entrepreneurial Talents of "Grassland Talents" Project of Inner Mongolia Autonomous Region Q2017042
6 · The paper itself

Abstract

Extracellular vesicles (EVs) derived from human bone marrow mesenchymal stem cells (BMSCs) are suggested to promote angiogenesis in a rat model of acute myocardial infarction (AMI). This study aimed to explore the underlying mechanism of BMSCs-EVs in AMI-induced heart failure (HF). BMSCs were isolated and verified, and EVs were purified and identified. After establishment of AMI-induced HF models, rats were treated with BMSCs-EVs and/or overexpressing (ov)/knocking down (kd) bone morphogenetic protein 2 (BMP2). Cardiac function, myocardial histopathological changes, angiogenesis, and vascular regeneration density were measured. Levels of pro-angiogenesis factors and cardiomyocyte apoptosis were detected. The viability and angiogenesis of hypoxic human umbilical vein endothelial cells (HUVECs) were measured. After BMSCs-EV treatment, the cardiac function of HF rats was improved, myocardial fibrosis and inflammatory cell infiltration were decreased, angiogenesis was increased, and cardiomyocyte apoptosis was inhibited. BMP2 was significantly upregulated in the myocardium. Ov-BMP2-BMSCs-EVs alleviated myocardial fibrosis and inflammatory cell infiltration, and promoted angiogenesis of HF rats, and improved the activity and angiogenesis of hypoxic HUVECs, while kd-BMP2-BMSCs-EVs showed limited protection against AMI-induced HF. BMSCs-EVs deliver BMP2 to promote angiogenesis and improve cardiac function of HF rats.

Indexed as

Extracellular VesiclesHeart FailureMesenchymal Stem CellsMyocardial InfarctionAnimalsBone Marrow CellsFibrosisHumansHuman Umbilical Vein Endothelial CellsRatsAcute myocardial infarctionAngiogenesisBMP2Bone marrow-derived mesenchymal stem cellsCardiac functionExtracellular vesiclesHeart failure

Identifiers

PMID35524813
OpenAlexW4229027840

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.