ArticleMagnetic resonance in medicine2022
Development of specialized magnetic resonance acquisition techniques for human hyperpolarized [
Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Hyperpolarized MRI in Oncology-A Review of Clinical Studies and Evaluation of Preclinical Liver Studies.NMR in biomedicine · 2026Review
- Feasibility of co-polarizing ¹³C-pyruvate and ¹³C-tert-butanol for simultaneous metabolic and perfusion imaging.Npj imaging · 2026Article
- Pharmacokinetic modeling strategies for dynamic hyperpolarized urea imaging.Magnetic resonance in medicine · 2026Article
- Three-dimensional high-resolution TMagnetic resonance in medicine · 2025Article
- A pathway toward clinical translation of hyperpolarized [1,4-Magnetic resonance in medicine · 2025Article
- Open-source implementation of X-nuclear sequences using the Pulseq framework.Magnetic resonance in medicine · 2025Article
- A flexible MRF approach to improve kinetic rate estimation with bSSFP-based hyperpolarized [1-Magnetic resonance in medicine · 2025Article
- Carbon-13 Hyperpolarization of α-Ketocarboxylates with Parahydrogen in Reversible Exchange.ChemMedChem · 2025Article
- Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025Review
- Translation of hyperpolarized [Npj imaging · 2025Article
- Awake brain MRSI reveals anesthetic sensitivity and regional aging effects on [Frontiers in neuroimaging · 2025Article
- Data Format Standardization and DICOM Integration for HyperpolarizedJournal of imaging informatics in medicine · 2024Article
- A pharmacokinetic model for hyperpolarizedMagnetic resonance in medicine · 2024Article
- Current methods for hyperpolarized [1-Magnetic resonance in medicine · 2024Review
- Article
- Hyperpolarized Carbon-13 Magnetic Resonance Imaging: Technical Considerations and Clinical Applications.Korean journal of radiology · 2024Review
- An Update on MR Spectroscopy in Cancer Management: Advances in Instrumentation, Acquisition, and Analysis.Radiology. Imaging cancer · 2024Review
- New Horizons in HyperpolarizedMolecular imaging and biology · 2024Article
- Investigating cerebral perfusion with high resolution hyperpolarized [1-Magnetic resonance in medicine · 2023Article
- Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1-Journal of magnetic resonance open · 2023Article
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeThis study aimed to develop and demonstrate the in vivo feasibility of a 3D stack-of-spiral balanced steady-state free precession(3D-bSSFP) urea sequence, interleaved with a metabolite-specific gradient echo (GRE) sequence for pyruvate and metabolic products, for improving the SNR and spatial resolution of the first hyperpolarized
methodsA metabolite-specific bSSFP urea imaging sequence was designed using a urea-specific excitation pulse, optimized TR, and 3D stack-of-spiral readouts. Simulations and phantom studies were performed to validate the spectral response of the sequence. The image quality of urea data acquired by the 3D-bSSFP sequence and the 2D-GRE sequence was evaluated with 2 identical injections of co-hyperpolarized [1-
resultsSimulations and phantom studies demonstrated that 3D-bSSFP sequence achieved urea-only excitation, while minimally perturbing other metabolites (<1%). An animal study demonstrated that compared to GRE, bSSFP sequence provided an ∼2.5-fold improvement in SNR without perturbing urea or pyruvate kinetics, and bSSFP approach with a shorter spiral readout reduced blurring artifacts caused by J-coupling of [
conclusionThe 3D-bSSFP urea sequence with a stack-of-spiral acquisition demonstrated significantly increased SNR and image quality for [
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.