Evidence map›Paper›PMID 35529848›Full record

ReviewFrontiers in immunology2022

Novel Biomarkers in Membranous Nephropathy.

Qiuying Liu, Jianhua Liu, Baoxu Lin, Yue Zhang, Meichen Ma, Mei Yang, Xiaosong Qin

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Qiuying LiuDepartment of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
Jianhua LiuDepartment of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
Baoxu LinDepartment of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
Yue ZhangDepartment of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
Meichen MaDepartment of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
Mei YangDepartment of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
Xiaosong QinDepartment of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
China Medical University · CNBeijing Haidian Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Membranous nephropathy (MN) is the main cause of adult nephrotic syndrome (NS). The pathogenesis of MN is complex and involves subepithelial immune complex deposition. Approximately one-third of patients with MN develop end-stage renal disease (ESRD). Timely diagnosis and reasonable intervention are the keys to improving prognosis. In recent years, with the development of high-throughput technologies, such as mass spectrometry (MS), microarray, and sequencing technologies, the discovery of biomarkers for MN has become an important area of research. In this review, we summarize the significant progress in biomarker identification. For example, a variety of podocyte target antigens and their autoantibodies have been reported. Phospholipase A2 receptor (PLA2R) is the most well-established target antigen in MN. PLA2R and its autoantibodies have clinical significance, with both diagnostic and therapeutic value for MN. In addition, a variety of new biomarkers, including proteins, metabolites, noncoding RNAs (ncRNAs), and immune cells, have recently been found. These MN-related biomarkers have great significance in the diagnosis, progression, prognosis, and treatment response of MN.

Indexed as

Glomerulonephritis, MembranousAdultAutoantibodiesBiomarkersFemaleHumansMalePrognosisReceptors, Phospholipase A2AutoantibodiesBiomarkersReceptors, Phospholipase A2biomarkerimmune cellmembranous nephropathymetabolomenoncoding RNAphospholipase A2 receptorproteome

Identifiers

PMID35529848
PMCPMC9074781
OpenAlexW4224223438

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.