Evidence map›Paper›PMID 35533254›Full record

ArticleMagnetic resonance in medicine2022

Lactate saturation limits bicarbonate detection in hyperpolarized

Nikolaj Bøgh, James T Grist, Camilla W Rasmussen, Lotte B Bertelsen, Esben S S Hansen, Jakob U Blicher, Damian J Tyler, Christoffer Laustsen

Open access · hybridAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Clinical Translation of HyperpolarizedAJNR. American journal of neuroradiology · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Spatial distribution of hyperpolarized [1-Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  7. Article
  8. Article
  9. Evidence ofMagnetic resonance in medicine · 2024
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Nikolaj BøghMR Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-0321-3269
James T GristDepartment of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, UK.ORCID 0000-0001-7223-4031
Camilla W RasmussenMR Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Lotte B BertelsenMR Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Esben S S HansenMR Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Jakob U BlicherCenter for Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark.
Damian J TylerDepartment of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, UK.
Christoffer LaustsenMR Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-0317-2911
Aarhus University · DKUniversity of Oxford · GB

Funding

British Heart Foundation FS/10/002/28078British Heart Foundation FS/14/17/30634Medical Research Council G0601490
6 · The paper itself

Abstract

purposeTo investigate the potential effects of [1-

methodsThirteen healthy rats underwent MRI with hyperpolarized [1-

resultsIn the brain, the [

conclusionsRadiofrequency saturation pulses on [1-

Indexed as

BicarbonatesPyruvic AcidAnimalsBrainCarbon IsotopesLactic AcidMagnetic Resonance ImagingRatsBicarbonatesCarbon IsotopesLactic AcidPyruvic Acidastrocyte neuron lactate shuttlebrainhyperpolarizedmagnetic resonance imagingmetabolismpyruvate

Identifiers

PMID35533254
PMCPMC9322338
OpenAlexW4229451030

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.