SynthesisNature communications2022
Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex.
Synthesis in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 126 citations in OpenAlex.
- Spatiotemporal mapping of brain organisation following the administration of 2C-B and psilocybin.Molecular psychiatry · 2026Trial
- Spatiotemporal white-matter development across early childhood.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Human brain connectome profiles mediate the relationship between pathology burden and clinical phenotypes in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The genetic architecture of cortical similarity networks.Nature communications · 2026Article
- DTI-ALPS and subcortical structural-functional coupling mediate the impact of sleep quality on working memory in insomnia disorder.Psychological medicine · 2026Article
- Decreased amyloid-related structure-function coupling in preclinical Alzheimer's disease.Communications medicine · 2026Article
- Structure-function coupling of large-scale cortical networks across the lifespan is spectrally specific.Communications biology · 2026Article
- Developmental changes of the white matter functional connectome.Molecular psychiatry · 2026Article
- Article
- Structuro-Functional Differentiation and Coupling of Gyri and Sulci in the Neonatal Cortex.Human brain mapping · 2026Article
- Decoupling of neurophysiological activity from structure mirrors global microarchitectural and neuromodulatory trends.Communications biology · 2026Article
- Brain functional-structural gradient coupling reflects development, behavior and genetic influences.Nature communications · 2026Article
- Exploring the Role of the Rich Club in Network Control of Neurocognitive States.Human brain mapping · 2026Article
- Bridging glucose metabolism and intrinsic functional organization of the human cortex.Communications biology · 2026Article
- Neurodevelopmentally rooted epicenters in schizophrenia: sensorimotor-association spatial axis of cortical thickness alterations.Molecular psychiatry · 2026Article
- Connectivity and function are coupled across cognitive domains throughout the brain.Network neuroscience (Cambridge, Mass.) · 2026Article
- Lifestyle and Transcriptional Signatures Associated with Ethnicity/Race-Related Variations in the Functional Connectome.Research (Washington, D.C.) · 2026Article
- The neuro-immuno-metabolic axis of exercise: a unified mechanistic framework for exercise-induced cognitive enhancement and psychological resilience.Frontiers in psychology · 2026Review
- Review
- Cross-Species Cortical Geometry Reveals Conserved Gradients Across Primates and Human-Specific Expansion.bioRxiv : the preprint server for biology · 2025Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 8 institutions in 7 countries.
Funding
Abstract
Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to understand how the macroscale organization of structure-function coupling across the cortex can inform its role in cognition. In humans, structure-function coupling was highest in regions of unimodal cortex and lowest in transmodal cortex, a pattern that was mirrored by a reduced alignment with heritable connectivity profiles. Structure-function uncoupling in macaques had a similar spatial distribution, but we observed an increased coupling between structure and function in association cortices relative to humans. Meta-analysis suggested regions with the least genetic control (low heritable correspondence and different across primates) are linked to social-cognition and autobiographical memory. Our findings suggest that genetic and evolutionary uncoupling of structure and function in different transmodal systems may support the emergence of complex forms of cognition.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.