Evidence map›Paper›PMID 35534740›Full record

ArticleCellular and molecular life sciences : CMLS2022

Inositol hexakisphosphate primes syndapin I/PACSIN 1 activation in endocytosis.

Yue Shi, Kaixuan Zhao, Guang Yang, Jia Yu, Yuxin Li, Michael M Kessels, Lina Yu, Britta Qualmann, Per-Olof Berggren, Shao-Nian Yang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. In Vivo CaBiomedicines · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Yue Shi *The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1, 171 76, Stockholm, Sweden. yue.shi@ki.se.
Kaixuan Zhao *The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1, 171 76, Stockholm, Sweden.
Guang YangThe Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1, 171 76, Stockholm, Sweden.
Jia YuThe Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1, 171 76, Stockholm, Sweden.
Yuxin LiNational Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun, 130024, China.
Michael M KesselsInstitute for Biochemistry I, Jena University Hospital/Friedrich Schiller University Jena, 07743, Jena, Germany.
Lina YuThe Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1, 171 76, Stockholm, Sweden.
Britta QualmannInstitute for Biochemistry I, Jena University Hospital/Friedrich Schiller University Jena, 07743, Jena, Germany.
Per-Olof BerggrenThe Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1, 171 76, Stockholm, Sweden. per-olof.berggren@ki.se.
Shao-Nian YangThe Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1, 171 76, Stockholm, Sweden. shao-nian.yang@ki.se.ORCID http://orcid.org/0000-0001-7470-7197
Karolinska University Hospital · SEJena University Hospital · DENortheast Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endocytosis is controlled by a well-orchestrated molecular machinery, where the individual players as well as their precise interactions are not fully understood. We now show that syndapin I/PACSIN 1 is expressed in pancreatic β cells and that its knockdown abrogates β cell endocytosis leading to disturbed plasma membrane protein homeostasis, as exemplified by an elevated density of L-type Ca

Indexed as

Cytoskeletal ProteinsPhytic AcidCarrier ProteinsEndocytosisPhosphorylationCarrier ProteinsCytoskeletal ProteinsPhytic AcidCa2+ channelCapacitance measurementCasein kinaseEndocytosisFM1-43 imagingSyndapin/PACSIN

Identifiers

PMID35534740
PMCPMC9085685
OpenAlexW4229370788

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.