Evidence map›Paper›PMID 35535908›Full record

ArticleNeural regeneration research2022

Obstructive sleep apnea aggravates neuroinflammation and pyroptosis in early brain injury following subarachnoid hemorrhage via ASC/HIF-1α pathway.

Jun Xu, Qian Li, Chen-Yu Xu, Shan Mao, Jia-Jia Jin, Wei Gu, Ying Shi, Chun-Fang Zou, Liang Ye

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jun XuDepartment of Respiration, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Qian LiDepartment of Respiration, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Chen-Yu XuDepartment of Respiration, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Shan MaoDepartment of Respiration, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Jia-Jia JinDepartment of Respiration, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Wei GuDepartment of Respiration, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Ying ShiDepartment of Respiration, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Chun-Fang ZouDepartment of Respiration, Nanjing First Hospital, Nanjing Medical University; Department of Respiration, Nanjing Yuhua Hospital, Yuhua Branch of Nanjing First Hospital, Nanjing, Jiangsu Province, China.
Liang YeDepartment of Respiration, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obstructive sleep apnea can worsen the prognosis of subarachnoid hemorrhage. However, the underlying mechanism remains unclear. In this study, we established a mouse model of subarachnoid hemorrhage using the endovascular perforation method and exposed the mice to intermittent hypoxia for 8 hours daily for 2 consecutive days to simulate sleep apnea. We found that sleep apnea aggravated brain edema, increased hippocampal neuron apoptosis, and worsened neurological function in this mouse model of subarachnoid hemorrhage. Then, we established an in vitro HT-22 cell model of hemin-induced subarachnoid hemorrhage/intermittent hypoxia and found that the cells died, and lactate dehydrogenase release increased, after 48 hours. We further investigated the underlying mechanism and found that sleep apnea increased the expression of hippocampal neuroinflammatory factors interleukin-1β, interleukin-18, interleukin-6, nuclear factor κB, pyroptosis-related protein caspase-1, pro-caspase-1, and NLRP3, promoted the proliferation of astrocytes, and increased the expression of hypoxia-inducible factor 1α and apoptosis-associated speck-like protein containing a CARD, which are the key proteins in the hypoxia-inducible factor 1α/apoptosis-associated speck-like protein containing a CARD signaling pathway. We also found that knockdown of hypoxia-inducible factor 1α expression in vitro greatly reduced the damage to HY22 cells. These findings suggest that sleep apnea aggravates early brain injury after subarachnoid hemorrhage by aggravating neuroinflammation and pyroptosis, at least in part through the hypoxia-inducible factor 1α/apoptosis-associated speck-like protein containing a CARD signaling pathway.

Indexed as

apoptosis associated speck like protein containing a CARDearly brain injuryhypoxia-inducible factor 1αneuroinflammationnucleotide-binding domain and leucine-rich repeat protein 3obstructive sleep apneapyroptosissubarachnoid hemorrhage

Identifiers

PMID35535908
PMCPMC9120669
OpenAlexW4226053324

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.