ArticleNeurobiology of aging2022
Longitudinal associations of absolute versus relative moderate-to-vigorous physical activity with brain microstructural decline in aging.
Article in Neurobiology of aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Long-term physical activity, brain structure, and cognitive function: a systematic review of longitudinal observational evidence.BMC neurology · 2026Pooled it
- Physical Activity and BrainAGE: Exploring the Impact on Brain Health and Plasticity in Older Adults.Human brain mapping · 2025Trial
- Microstructural Brain Reserve Moderates the Associations Between 24-h Movement Behaviors and Cognition in Older Adults: Cross-Sectional Findings From the AGUEDA Trial.Scandinavian journal of medicine & science in sports · 2026Article
- Early Microstructural Changes in the Left Inferior Fronto-Occipital Fasciculus: A Key Factor in Probable Alzheimer's Disease Patients With Slow Gait Speed.Brain and behavior · 2026Article
- Physical Activity Patterns and Variability, Cognitive Performance, and Dementia in the National Health and Aging Trends Study.Medicine and science in sports and exercise · 2025Article
- Independent associations of sleep and physical activity with cognition are mediated by hippocampal microstructure in middle-aged and older adults.Neurobiology of aging · 2025Article
- Assessing Exercise and Fitness-Related Brain Health Using Multi-modal Magnetic Resonance Imaging Outcomes.Advances in neurobiology · 2025Review
- Circulating Neurofilament Light Chain Levels Increase with Age and Are Associated with Worse Physical Function and Body Composition in Men but Not in Women.International journal of molecular sciences · 2023Article
- Lower Myelin Content Is Associated With Lower Gait Speed in Cognitively Unimpaired Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Investigating Links between Moderate-to-Vigorous Physical Activity and Self-Rated Health Status in Adolescents: The Mediating Roles of Emotional Intelligence and Psychosocial Stress.Children (Basel, Switzerland) · 2023Article
- Dual cognitive and mobility impairments and future dementia - Setting a research agenda.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Machine learning for predicting neurodegenerative diseases in the general older population: a cohort study.BMC medical research methodology · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Higher moderate-to-vigorous intensity (MVPA) may preserve brain structural integrity, but evidence is mostly cross-sectional and relies on absolute PA measures. We examined longitudinal associations of absolute MVPA using population-level activity count thresholds and relative MVPA using individual heart rate reserve (HRR) via Actiheart with subsequent changes in brain diffusion tensor imaging (DTI) over average of 3.8 years in 248 initially cognitively normal individuals (56-91 years). DTI markers included areas important for memory (temporal areas), executive (prefrontal cortex, superior longitudinal fasciculus), and motor function (precentral gyrus, putamen, caudate, body of corpus callosum). Associations of MVPA with changes in DTI markers were examined using linear mixed-effects models, adjusted for demographics and apolipoprotein e4 carrier status. Each additional 22 min of relative MVPA per day was significantly associated with less decline in fractional anisotropy of uncinate fasciculus and cingulum-hippocampal part and with less increase in mean diffusivity of entorhinal cortex and parahippocampal gyrus. Absolute MVPA was not associated with DTI changes. More time spent in relative MVPA by HRR may prevent brain microstructural decline in selected temporal areas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.