Evidence map›Paper›PMID 35545731›Full record

ArticleHuman cell2022

Serum-derived extracellular vesicles mediate Smad4 expression through shuttling microRNA-27a in the progression of laryngeal squamous cell carcinoma.

Yu Shuang, Xiaofeng Yao, Jing Liu, Juntao Niu, Wenyu Guo, Chao Li

Abstract read
PubMed Publisher
In one paragraph

Article in Human cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yu ShuangDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Hospital of Tianjin Medical University, No. 23, Pingjiang Road, Tianjin, 300211, People's Republic of China. yushuang_11252@126.com.
Xiaofeng YaoDepartment of Maxillofacial and Otorhinolaryngology Head and Neck Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjing, 300202, People's Republic of China.
Jing LiuDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Hospital of Tianjin Medical University, No. 23, Pingjiang Road, Tianjin, 300211, People's Republic of China.
Juntao NiuDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Hospital of Tianjin Medical University, No. 23, Pingjiang Road, Tianjin, 300211, People's Republic of China.
Wenyu GuoDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Hospital of Tianjin Medical University, No. 23, Pingjiang Road, Tianjin, 300211, People's Republic of China.
Chao LiDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Hospital of Tianjin Medical University, No. 23, Pingjiang Road, Tianjin, 300211, People's Republic of China.
Tianjin Medical University · CNSecond Hospital of Tianjin Medical University · CNTianjin Medical University Cancer Institute and Hospital · CN

Funding

Clinical medicine research project of the second hospital of Tianjin Medical University 2020LC08
6 · The paper itself

Abstract

Serum-derived extracellular vesicles (EVs) containing non-coding RNAs have been indicated to serve as diagnostic and prognostic biomarkers for laryngeal squamous cell carcinoma (LSCC), while their functional role remains to be explored. Here, we summarize the possible mechanism explaining the laryngeal carcinogenesis and the associated changes with the involvement of extracellular microRNA (miR)-27a from serum of LSCC patients. Serum-derived EVs from LSCC patients were found to increase the proliferative activity and decreased the apoptotic activity of LSCC cells. miRNA microarrays revealed that miR-27a expression was elevated after EV treatment. miR-27a expression was elevated in LSCC tissues and predicted a poor prognosis for patients. Downregulation of miR-27a inhibited the effect of EVs to reduce the activity of LSCC cells in vitro and to suppress tumor development in vivo. miR-27a targeted SMAD family member 4 (Smad4) to mediate the Wnt/β-catenin pathway, which was induced under the influence of EVs. Smad4 was downregulated in LSCC tissues, and simultaneous overexpression of miR-27a and Smad4 resulted in reduced cell activity and tumorigenicity. In conclusion, serum-derived EVs support the laryngeal carcinogenesis at least partially via transferring miR-27a. miR-27a targets Smad4 and is a biomarker to predict LSCC prognosis.

Indexed as

Carcinoma, Squamous CellExtracellular VesiclesHead and Neck NeoplasmsLaryngeal NeoplasmsMicroRNAsCarcinogenesisCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansSmad4 ProteinSquamous Cell Carcinoma of Head and NeckMicroRNAsSmad4 ProteinSMAD4 protein, humanExtracellular vesiclesLaryngeal squamous cell carcinomamicroRNA-27aSmad4Wnt/β-catenin pathway

Identifiers

PMID35545731
OpenAlexW4280628915

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.