Evidence map›Paper›PMID 35547157›Full record

ArticleFrontiers in bioengineering and biotechnology2022

Superior Fluorescent Nanoemulsion Illuminates Hepatocellular Carcinoma for Surgical Navigation.

Jing Zhu, Chengchao Chu, Dongsheng Li, Yang Zhang, Yi Cheng, Huirong Lin, Xiaoyong Wang, Junxian Liu, Xin Pang, Jingliang Cheng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jing ZhuDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Chengchao ChuCenter for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China.
Dongsheng LiCenter for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China.
Yang ZhangCenter for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China.
Yi ChengCenter for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China.
Huirong LinCenter for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China.
Xiaoyong WangCenter for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China.
Junxian LiuCenter for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China.
Xin PangDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jingliang ChengDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Gang LiuCenter for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC), the fifth most common cancer worldwide, poses a severe threat to public health. Intraoperative fluorescence imaging provides a golden opportunity for surgeons to visualize tumor-involved margins, thereby implementing precise HCC resection with minimal damage to normal tissues. Here, a novel-acting contrast agent, which facilely bridges indocyanine green (ICG) and lipiodol using self-emulsifying nanotechnology, was developed for optical surgical navigation. Compared to clinically available ICG probe, our prepared nanoemulsion showed obviously red-shifted optical absorption and enhanced fluorescence intensity. Further benefiting from the shielding effect of lipiodol, the fluorescence stability and anti-photobleaching ability of nanoemulsion were highly improved, indicating a great capacity for long-lasting

Indexed as

fluorescence imagingHepatocellular Carcinomaindocyanine greennanoemulsionsurgical navigation

Identifiers

PMID35547157
PMCPMC9081524

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.