ArticleThe Journal of experimental medicine2022
GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans.
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Article in The Journal of experimental medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
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14 citing papers in PubMed, 23 citations in OpenAlex.
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- Human inborn errors of immunity: 2024 update on the classification from the International Union of Immunological Societies Expert Committee.Journal of human immunity · 2025Article
- Uncovering Hippo pathway-related biomarkers in acute myocardial infarction via scRNA-seq binding transcriptomics.Scientific reports · 2025Article
- AMBRA1 controls the translation of immune-specific genes in T lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The goat pan-genome reveals patterns of gene loss during domestication.Journal of animal science and biotechnology · 2024Article
- Spatial multiomics of arterial regions from cardiac allograft vasculopathy rejected grafts reveal novel insights into the pathogenesis of chronic antibody-mediated rejection.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- Identification and validation of GIMAP family genes as immune-related prognostic biomarkers in lung adenocarcinoma.Heliyon · 2024Article
- Investigation and verification of GIMAP6 as a robust biomarker for prognosis and tumor immunity in lung adenocarcinoma.Journal of cancer research and clinical oncology · 2023Article
- Screening and identifying a novel M-MDSCs-related gene signature for predicting prognostic risk and immunotherapeutic responses in patients with lung adenocarcinoma.Frontiers in genetics · 2022Article
Corrections and comments
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Authors and funding
44 authors at 14 institutions in 6 countries.
Yikun Yao *Molecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-8890-2409
Ping Du Jiang *Molecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-9900-8277
Brittany N Chao *Molecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-0355-2332
Deniz Cagdas *Division of Immunology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.ORCID 0000-0003-2213-4627
Satoshi KuboMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0001-9693-9263
Arasu BalasubramaniyamCrystallography, Max-Delbrück-Centrum for Molecular Medicine in the Helmholtz Association, Berlin, Germany.ORCID 0000-0003-4168-8617
Yu ZhangHuman Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Rockville, MD.ORCID 0000-0002-6904-0372
Bella ShadurHadassah University Medical Center, Department of Bone Marrow Transplantation and Cancer Immunotherapy, Jerusalem, Israel.ORCID 0000-0003-0245-894X
Adeeb NaserEddinHadassah University Medical Center, Department of Bone Marrow Transplantation and Cancer Immunotherapy, Jerusalem, Israel.ORCID 0000-0001-6995-3262
Les R FolioClinical Center, National Institutes of Health, Bethesda, MD.
Benjamin SchwarzLaboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, Rockville, MD.ORCID 0000-0002-5894-953X
Eric BohrnsenLaboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, Rockville, MD.ORCID 0000-0003-4327-5242
Lixin ZhengMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-8838-8665
Matthew LynbergMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0003-1371-3002
Simone GottliebMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0003-0550-4761
Michael A Leney-GreeneMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-3259-1728
Ann Y ParkMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-0130-1521
Ilhan TezcanDivision of Immunology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.ORCID 0000-0001-7257-4554
Ali AkdoganDivision of Rheumatology, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Rahsan GocmenDepartment of Radiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.ORCID 0000-0002-0223-9336
Sevgen OnderDepartment of Pathology, Hacettepe University Faculty of Medicine, Ankara, Turkey.ORCID 0000-0002-5523-0669
Avi RosenbergKidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Elizabeth J SoilleuxDepartment of Pathology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-4032-7249
Errin JohnsonThe Dunn School of Pathology, South Parks Road, Oxford, UK.ORCID 0000-0001-8435-9472
Peter K JacksonBaxter Laboratory, Departments of Microbiology & Immunology and Pathology Stanford University School of Medicine, Stanford, CA.ORCID 0000-0002-1742-2539
Janos DemeterBaxter Laboratory, Departments of Microbiology & Immunology and Pathology Stanford University School of Medicine, Stanford, CA.ORCID 0000-0002-7301-8055
Samuel D ChauvinMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0003-0232-751X
Florian PaulCrystallography, Max-Delbrück-Centrum for Molecular Medicine in the Helmholtz Association, Berlin, Germany.ORCID 0000-0001-5181-3122
Matthias SelbachCrystallography, Max-Delbrück-Centrum for Molecular Medicine in the Helmholtz Association, Berlin, Germany.ORCID 0000-0003-2454-8751
Haydar BulutCrystallography, Max-Delbrück-Centrum for Molecular Medicine in the Helmholtz Association, Berlin, Germany.ORCID 0000-0003-0262-6296
Menna R ClatworthyMolecular Immunity Unit, University of Cambridge Department of Medicine, Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-3340-9828
Zewen K TuongMolecular Immunity Unit, University of Cambridge Department of Medicine, Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-6735-6808
Hanlin ZhangKennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Oxford, UK.
Benjamin J StewartMolecular Immunity Unit, University of Cambridge Department of Medicine, Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0003-4522-0085
Catharine M BosioLaboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, Rockville, MD.ORCID 0000-0002-7332-9611
Polina StepenskyHadassah University Medical Center, Department of Bone Marrow Transplantation and Cancer Immunotherapy, Jerusalem, Israel.ORCID 0000-0002-4923-3660
Simon ClareHost-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK.ORCID 0000-0001-9368-6037
Sundar GanesanBiological Imaging Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, Rockville, MD.ORCID 0000-0003-1132-2016
John C PascallLaboratory of Lymphocyte Signalling and Development, Babraham Institute, Babraham Research Campus, Cambridge, UK.ORCID 0000-0002-9506-1441
Oliver DaumkeCrystallography, Max-Delbrück-Centrum for Molecular Medicine in the Helmholtz Association, Berlin, Germany.ORCID 0000-0002-6190-1414
Geoffrey W ButcherLaboratory of Lymphocyte Signalling and Development, Babraham Institute, Babraham Research Campus, Cambridge, UK.ORCID 0000-0002-3423-7124
Andrew J McMichael *Nuffield Department of Medicine Research Building, Roosevelt Drive, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-9101-7478
Anna Katharina Simon *Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Oxford, UK.ORCID 0000-0002-4077-7995
Michael J Lenardo *Molecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0003-1584-468X
National Institutes of Health · USMax Delbrück Center · DENational Institute of Allergy and Infectious Diseases · USHacettepe University · TRMRC Laboratory of Molecular Biology · GBUniversity of Oxford · GBBabraham Institute · GBHacettepe University Hospital · TRHadassah Medical Center · ILStanford University · USGarvan Institute of Medical Research · AUNational Institutes of Health Clinical Center · USUniversity of Cambridge · GBWellcome Sanger Institute · GB
Funding
Infectious Diseases Research Technologies Core - BethesdaZICAI001051 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CHERRY, JAMES · 2009 to 2025
$226.1MImmunity to Pulmonary InfectionsZIAAI001013 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BOSIO, CATHARINE · 2009 to 2025
$18.9MMolecular Mechanisms Of The Autoimmune Lymphoproliferative Syndrome And Other Immunoregulatory DisordersZIAAI000769 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SU, HELEN · 2009 to 2024
$16.7MGerman Research Foundation 958Hacettepe University Coordination Unit for Scientific Research ProjectsNational Institute of Allergy and Infectious DiseasesNHLBI NIH HHSOxford University
Abstract
Inborn errors of immunity (IEIs) unveil regulatory pathways of human immunity. We describe a new IEI caused by mutations in the GTPase of the immune-associated protein 6 (GIMAP6) gene in patients with infections, lymphoproliferation, autoimmunity, and multiorgan vasculitis. Patients and Gimap6-/- mice show defects in autophagy, redox regulation, and polyunsaturated fatty acid (PUFA)-containing lipids. We find that GIMAP6 complexes with GABARAPL2 and GIMAP7 to regulate GTPase activity. Also, GIMAP6 is induced by IFN-γ and plays a critical role in antibacterial immunity. Finally, we observed that Gimap6-/- mice died prematurely from microangiopathic glomerulosclerosis most likely due to GIMAP6 deficiency in kidney endothelial cells.
Indexed as
GTP PhosphohydrolasesImmunologic Deficiency SyndromesAnimalsAutophagyEndothelial CellsHumansInflammationMiceGIMAP6 protein, humanGTP Phosphohydrolases
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.