ArticleInternational journal of environmental research and public health2022
Cognitive Functions Associated with Brain Imaging Markers in Patients with Psoriasis.
Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Molecular Link Between Psoriasis and Depression-Update on Pathophysiology.International journal of molecular sciences · 2025Review
- Knowledge, Attitudes, and Practices of Elderly Diabetic Patients and Their Families Regarding Comorbid Non-Alcoholic Fatty Liver Disease: A Structural Equation Modeling Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Do Psoriasis and Atopic Dermatitis Affect Memory, Attention, Stress and Emotions?Brain sciences · 2024Article
- Do Atopic Dermatitis and Psoriasis Have an Impact on Cognitive Decline-Latest Research Review.Healthcare (Basel, Switzerland) · 2024Review
- Association between skin disease and anxiety: a logistic analysis and prediction.Annals of translational medicine · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psoriasis is a severe inflammatory disease associated with a higher comorbidity of depression, cognitive dysfunction and brain atrophy. The association between psoriasis, magnetic resonance imaging (MRI) markers and cognitive impairment has rarely been investigated, and the existing results are conflicting.
methodsThis study included 89 subjects (53 patients with psoriasis and 36 healthy controls). The severity of psoriasis was evaluated using the Psoriasis Area and Severity Index (PASI) score; for depression, the Hospital Anxiety and Depression Scale (HADS) scale was used. Neuropsychological tests were also applied, including a Trail Making Test (TMT) as well as Digit Span, Stroop, Verbal Fluency and Rey Auditory Verbal Learning tests. MRI scans were performed using a 1.5 T scanner. Brain volumetry, white matter lesions, grey matter and white matter were evaluated. The extent of these changes was assessed on the Fazekas scale. The differences between groups were evaluated using a Student's
resultsPatients with psoriasis presented worse achievements on all the neuropsychological tests and showed more intense changes on MRI compared to healthy controls. The severity of psoriasis as determined by PASI scores was associated with depression, and a greater psychomotor slowness severity of changes in the brain was associated with poorer results on the neurological tests.
conclusionsOur results indicate the possibility of progressive brain atrophy related to cognitive decline in psoriasis.
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