Evidence map›Paper›PMID 35565668›Full record

ReviewNutrients2022

Immunonutrition and SARS-CoV-2 Infection in Children with Obesity.

Enza D'Auria, Valeria Calcaterra, Elvira Verduci, Michele Ghezzi, Rossella Lamberti, Sara Vizzuso, Paola Baldassarre, Erica Pendezza, Veronica Perico, Alessandra Bosetti and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Enza D'AuriaPediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.ORCID 0000-0003-2750-5810
Valeria CalcaterraPediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.ORCID 0000-0002-2137-5974
Elvira VerduciPediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.ORCID 0000-0003-2111-3111
Michele GhezziPediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.ORCID 0000-0002-7434-9112
Rossella LambertiPediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.
Sara VizzusoPediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.
Paola BaldassarrePediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.
Erica PendezzaPediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.ORCID 0000-0002-4966-7389
Veronica PericoPediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.
Alessandra BosettiPediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.
Gian Vincenzo ZuccottiPediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.ORCID 0000-0002-2795-9874
Ospedale dei Bambini Vittore Buzzi · ITUniversity of Milan · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the beginning of the SARS-CoV-2 pandemic, there has been much discussion about the role of diet and antiviral immunity in the context of SARS-CoV-2 infection. Intake levels of vitamins D, C, B12, and iron have been demonstrated to be correlated with lower COVID-19 incidence and mortality. Obesity has been demonstrated to be an independent risk for the severity of COVID-19 infection in adults and also in children. This may be due to different mechanisms, mainly including the gut dysbiosis status observed in obese children. Moreover, the existence of a gut-lung axis added new knowledge to on the potential mechanisms by which diet and dietary substances may affect immune function. The aim of this narrative review is to address the intricate inter-relationship between COVID-19, immune function, and obesity-related inflammation and to describe the role of nutrients and dietary patterns in enhancing the immune system. Two ways to fight against COVID-19 disease exist: one with an antiviral response through immune system boosting and another with antioxidants with an anti-inflammatory effect. In the current pandemic situation, the intake of a varied and balanced diet, rich in micronutrients and bioactive compounds including fibers, should be recommended. However, clinical studies conducted on children affected by SARS-CoV-2 infection and comorbidity are warranted.

Indexed as

COVID-19Pediatric ObesityAdultChildHumansPandemicsSARS-CoV-2antiviral immunitydysbiosisgut–lung axisimmunonutritionmicronutrientsobesitySARS-CoV-2 infection

Identifiers

PMID35565668
PMCPMC9101404
OpenAlexW4224241824

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.