Evidence map›Paper›PMID 35566187›Full record

ArticleMolecules (Basel, Switzerland)2022

In Silico Molecular Docking Analysis of Karanjin against Alzheimer's and Parkinson's Diseases as a Potential Natural Lead Molecule for New Drug Design, Development and Therapy.

Charles Gnanaraj, Mahendran Sekar, Shivkanya Fuloria, Shasank S Swain, Siew Hua Gan, Kumarappan Chidambaram, Nur Najihah Izzati Mat Rani, Tavamani Balan, Sarah Stephenie, Pei Teng Lum and 6 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 84 citations in OpenAlex.

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  20. Exploring the potential ofJournal of Taibah University Medical Sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 3 countries.

Charles GnanarajFaculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh 30450, Malaysia.ORCID 0000-0001-9644-6688
Mahendran SekarDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh 30450, Malaysia.ORCID 0000-0002-3022-6137
Shivkanya FuloriaFaculty of Pharmacy, Centre of Excellence for Biomaterials Engineering, AIMST University, Bedong 08100, Malaysia.
Shasank S SwainDivision of Microbiology and NCDs, ICMR-Regional Medical Research Centre, Bhubaneswar 751023, India.ORCID 0000-0001-5089-8304
Siew Hua GanSchool of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, Malaysia.ORCID 0000-0001-6470-3651
Kumarappan ChidambaramDepartment of Pharmacology, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia.ORCID 0000-0002-7981-4562
Nur Najihah Izzati Mat RaniFaculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh 30450, Malaysia.
Tavamani BalanFaculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh 30450, Malaysia.
Sarah StephenieSchool of Biological Sciences, Faculty of Science and Technology, Quest International University Perak, Jalan Raja Permaisuri Bainun, Ipoh 30250, Malaysia.ORCID 0000-0003-4454-9612
Pei Teng LumDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh 30450, Malaysia.
Srikanth JeyabalanDepartment of Pharmacology, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai 600116, India.ORCID 0000-0003-3514-7654
M Yasmin BegumDepartment of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia.ORCID 0000-0002-1871-8585
Vivek ChandramohanDepartment of Biotechnology, Siddaganga Institute of Technology, Tumakuru 572103, India.
Lakshmi ThangaveluCenter for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, India.
Vetriselvan SubramaniyanFaculty of Medicine, Bioscience and Nursing, MAHSA University, Jalan SP 2, Bandar Saujana Putra, Jenjarom 42610, Malaysia.ORCID 0000-0002-9629-9494
Neeraj Kumar FuloriaFaculty of Pharmacy, Centre of Excellence for Biomaterials Engineering, AIMST University, Bedong 08100, Malaysia.
University of Kuala Lumpur · MYAIMST University · MYKing Khalid University · SAMahsa University · MYMonash University Malaysia · MYQuest International University Perak · MYRegional Medical Research Centre · INSaveetha University · INSiddaganga Institute of Technology · INSri Ramachandra Institute of Higher Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) and Alzheimer's disease (AD) are neurodegenerative disorders that have emerged as among the serious health problems of the 21st century. The medications currently available to treat AD and PD have limited efficacy and are associated with side effects. Natural products are one of the most vital and conservative sources of medicines for treating neurological problems. Karanjin is a furanoflavonoid, isolated mainly from

Indexed as

Alzheimer DiseaseParkinson DiseaseAnimalsBenzopyransDrug DesignMolecular Docking SimulationMolecular Dynamics SimulationBenzopyranskaranjinADMETAlzheimer’s diseasebioinformaticsdrug-likenessin silicokaranjinLipinski’s rulemolecular dynamicsParkinson’s disease

Identifiers

PMID35566187
PMCPMC9100660
OpenAlexW4225161572

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.