Evidence map›Paper›PMID 35567294›Full record

ReviewPhytotherapy research : PTR2022

Nutmeg (Myristica fragrans Houtt.) essential oil: A review on its composition, biological, and pharmacological activities.

Kaliyaperumal Ashokkumar, Jesus Simal-Gandara, Muthusamy Murugan, Mannananil Krishnankutty Dhanya, Arjun Pandian

Abstract readReview
In one paragraph

Review in Phytotherapy research : PTR, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Genome survey of nutmeg (Frontiers in plant science · 2026
    Article
  6. Multi-stage insecticide potentials ofCurrent research in parasitology & vector-borne diseases · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Wound-Healing Potential ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kaliyaperumal AshokkumarCardamom Research Station, Kerala Agricultural University, Idukki, Kerala, India.ORCID https://orcid.org/0000-0002-0440-6310
Jesus Simal-GandaraNutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, Universidade de Vigo, Ourense, Spain.ORCID https://orcid.org/0000-0001-9215-9737
Muthusamy MuruganCardamom Research Station, Kerala Agricultural University, Idukki, Kerala, India.ORCID https://orcid.org/0000-0001-9449-1039
Mannananil Krishnankutty DhanyaCardamom Research Station, Kerala Agricultural University, Idukki, Kerala, India.
Arjun PandianDepartment of Biotechnology, PRIST Deemed University, Thanjavur, Tamil Nadu, India.

Funding

Universidade de Vigo
6 · The paper itself

Abstract

Myristica fragrans (Houtt.) is an evergreen tree native to the Maluku Islands, Indonesia. M. fragrans kernel is extensively used in Indian traditional medicines to treat various diseases. Several studies attempt to compile and interpret the pharmacological potential of Myristica fragrans (Houtt.) aqueous and various chemical extracts. Thus, the pharmacological potential of nutmeg essential oil has not been reviewed phytochemically and pharmacologically. Therefore, the present study aimed to share appropriate literature evidence regarding the plant essential oil chemical composition and therapeutic potential of Myristica fragrans essential oil (MFEO). MFEO of leaf, mace, kernel, and seed were used worldwide as potential Ayurvedic medicine and fragrance. MFEO extracted by various methods and oil yield was 0.7-3.2, 8.1-10.3, 0.3-12.5, and 6.2-7.6% in leaf, mace, seed, and kernel. The primary chemical constituents of MFEO were sabinene, eugenol, myristicin, caryophyllene, β-myrcene, and α-pinene. Clinical and experimental investigations have confirmed the antioxidant, antimicrobial, antiinflammatory, anticancer, antimalarial, anticonvulsant, hepatoprotective, antiparasitic, insecticidal, and nematocidal activities of MFEO. It is the first attempt to compile oil yield, composition, and the biological activities of MFEO. In future, several scientific investigations are required to understand the mechanism of action of MFEO and their bioactive constituents.

Indexed as

Anti-Infective AgentsMyristicaOils, VolatileAntioxidantsPlant ExtractsSeedsAnti-Infective AgentsAntioxidantsOils, VolatilePlant Extractsbiological activitieschemical compositionessential oilMyristica fragransmyristicinnutmegsabinene

Identifiers

PMID35567294
PMCPMC9541156

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.