Evidence map›Paper›PMID 35573135›Full record

ArticleEngineering in life sciences2022

Characterization of a novel microfluidic platform for the isolation of rare single cells to enable CTC analysis from head and neck squamous cell carcinoma patients.

Janis Stiefel, Christian Freese, Ashwin Sriram, Sabine Alebrand, Nalini Srinivas, Christoph Sproll, Madita Wandrey, Désirée Gül, Jan Hagemann, Jürgen C Becker and 1 more

Abstract read
In one paragraph

Article in Engineering in life sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Redefining oropharyngeal cancer in the HPV era: integrating precision medicine and immunotherapeutic frontiers.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
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  6. Recent Advances in Methods for Circulating Tumor Cell Detection.International journal of molecular sciences · 2023
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Janis StiefelFraunhofer Institute for Microengineering and Microsystems IMM Mainz Germany.ORCID https://orcid.org/0000-0002-1166-4326
Christian FreeseFraunhofer Institute for Microengineering and Microsystems IMM Mainz Germany.ORCID https://orcid.org/0000-0001-8411-1573
Ashwin SriramTranslational Skin Cancer Research DKTK Partner Site Essen/Düsseldorf West German Cancer Center Dermatology University Duisburg-Essen, Essen, Germany; German Cancer Research Center (DKFZ) Heidelberg Germany.
Sabine AlebrandFraunhofer Institute for Microengineering and Microsystems IMM Mainz Germany.
Nalini SrinivasTranslational Skin Cancer Research DKTK Partner Site Essen/Düsseldorf West German Cancer Center Dermatology University Duisburg-Essen, Essen, Germany; German Cancer Research Center (DKFZ) Heidelberg Germany.ORCID https://orcid.org/0000-0002-6899-0800
Christoph SprollClinic for Oral and Maxilofacial Surgery Düsseldorf University Hospital Heinrich-Heine-University Düsseldorf Germany.
Madita WandreyDepartment of Otorhinolaryngology/ENT University Medical Center Mainz Germany.
Désirée GülDepartment of Otorhinolaryngology/ENT University Medical Center Mainz Germany.ORCID https://orcid.org/0000-0002-2446-5756
Jan HagemannDepartment of Otorhinolaryngology/ENT University Medical Center Mainz Germany.ORCID https://orcid.org/0000-0002-9846-7850
Jürgen C BeckerTranslational Skin Cancer Research DKTK Partner Site Essen/Düsseldorf West German Cancer Center Dermatology University Duisburg-Essen, Essen, Germany; German Cancer Research Center (DKFZ) Heidelberg Germany.ORCID https://orcid.org/0000-0001-9183-653X
Michael BaßlerFraunhofer Institute for Microengineering and Microsystems IMM Mainz Germany.ORCID https://orcid.org/0000-0003-3911-2897

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Detailed examination of tumor components is leading-edge to establish personalized cancer therapy. Accompanying research on cell-free DNA, the cell count of circulating tumor cells (CTCs) in patient blood is seen as a crucial prognostic factor. The potential of CTC analysis is further not limited to the determination of the overall survival rate but sheds light on understanding inter- and intratumoral heterogeneity. In this regard, commercial CTC isolation devices combining an efficient enrichment of rare cells with a droplet deposition of single cells for downstream analysis are highly appreciated. The Liquid biopsy platform

Indexed as

automationliquid biopsymicrofluidicsprecision medicinetumor diagnostics

Identifiers

PMID35573135
PMCPMC9077830

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.