Evidence map›Paper›PMID 35575293›Full record

Trial reportThe Journal of physiology2022

Rho-kinase inhibition improves haemodynamic responses and circulating ATP during hypoxia and moderate intensity handgrip exercise in healthy older adults.

Matthew L Racine, Janée D Terwoord, Nathaniel B Ketelhut, Nate P Bachman, Jennifer C Richards, Gary J Luckasen, Frank A Dinenno

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Rho/ROCK Pathway as a Therapeutic Target in Multiple Diseases.International journal of drug discovery and pharmacology · 2025
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Matthew L RacineHuman Cardiovascular Physiology Laboratory, Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0002-8377-3556
Janée D TerwoordHuman Cardiovascular Physiology Laboratory, Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA.
Nathaniel B KetelhutHuman Cardiovascular Physiology Laboratory, Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0001-7034-4237
Nate P BachmanHuman Cardiovascular Physiology Laboratory, Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA.
Jennifer C RichardsHuman Cardiovascular Physiology Laboratory, Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA.
Gary J LuckasenMedical Center of the Rockies, University of Colorado Health, Loveland, CO, USA.
Frank A DinennoHuman Cardiovascular Physiology Laboratory, Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0003-4644-3213
Colorado State University · USUniversity of Arkansas Medical Center · US

Funding

Training in Signature Transdisciplinary Cardiovascular SciencesT32HL134643 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Justin L Grobe, Jacquelyn P Kulinski · 2017 to 2026
$4.2M
Exercise Hyperemia in HumansR01HL119337 · NHLBI · MAYO CLINIC ROCHESTER · PI DINENNO, FRANK A, JOYNER, MICHAEL J · 2014 to 2017
$3.0M
Mechanisms and treatment of impaired erythrocyte ATP release in older adultsF31HL126377 · NHLBI · COLORADO STATE UNIVERSITY · PI RACINE, MATTHEW · 2015 to 2017
$103k
NHLBI NIH HHS F31 HL126377NHLBI NIH HHS R01 HL119337NHLBI NIH HHS T32 HL134643
6 · The paper itself

Abstract

Skeletal muscle haemodynamics and circulating adenosine triphosphate (ATP) responses during hypoxia and exercise are blunted in older (OA) vs. young (YA) adults, which may be associated with impaired red blood cell (RBC) ATP release. Rho-kinase inhibition improves deoxygenation-induced ATP release from OA isolated RBCs. We tested the hypothesis that Rho-kinase inhibition (via fasudil) in vivo would improve local haemodynamic and ATP responses during hypoxia and exercise in OA. Healthy YA (25 ± 3 years; n = 12) and OA (65 ± 5 years; n = 13) participated in a randomized, double-blind, placebo-controlled, crossover study on two days (≥5 days between visits). A forearm deep venous catheter was used to administer saline/fasudil and sample venous plasma ATP ([ATP]

Indexed as

Adenosine TriphosphateHand StrengthAdultCross-Over StudiesForearmHemodynamicsHumansHypoxiaMuscle, SkeletalRegional Blood Flowrho-Associated KinasesYoung AdultAdenosine Triphosphaterho-Associated KinasesageingATPblood flowexercisefasudilhypoxia

Identifiers

PMID35575293
PMCPMC9288513
OpenAlexW4280509327

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.