Evidence map›Paper›PMID 35575516›Full record

ArticleJournal of visualized experiments : JoVE2022

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor.

Andrew D Tieniber, Andrew N Hanna, Kevin Do, Laura Wang, Ferdinando Rossi, Ronald P DeMatteo

Abstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of visualized experiments : JoVE, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Andrew D TieniberDepartment of Surgery, Hospital of the University of Pennsylvania.
Andrew N HannaDepartment of Surgery, Hospital of the University of Pennsylvania.
Kevin DoDepartment of Surgery, Hospital of the University of Pennsylvania.
Laura WangDepartment of Surgery, Hospital of the University of Pennsylvania.
Ferdinando RossiDepartment of Surgery, Hospital of the University of Pennsylvania.
Ronald P DeMatteoDepartment of Surgery, Hospital of the University of Pennsylvania; Ronald.DeMatteo@pennmedicine.upenn.edu.
Hospital of the University of Pennsylvania · US

Funding

Molecular Mechanisms in Gastrointestinal Stromal TumorR01CA102613 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Ronald P. Dematteo · 2004 to 2026
$9.2M
SURGICAL ONCOLOGY RESEARCH TRAINING PROGRAM AT PENNT32CA251063 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Ronald P. Dematteo · 2020 to 2026
$2.6M
NCI NIH HHS R01 CA102613NCI NIH HHS T32 CA251063
6 · The paper itself

Abstract

Gastrointestinal stromal tumor (GIST) is the most common human sarcoma and is typically driven by a single mutation in the KIT receptor. Across tumor types, numerous mouse models have been developed in order to investigate the next generation of cancer therapies. However, in GIST, most in vivo studies use xenograft mouse models which have inherent limitations. Here, we describe an immunocompetent, genetically engineered mouse model of gastrointestinal stromal tumor harboring a Kit

Indexed as

Gastrointestinal Stromal TumorsAnimalsDisease Models, AnimalHumansImmunologic TechniquesMiceMutationProto-Oncogene Proteins c-kitProto-Oncogene Proteins c-kit

Identifiers

PMID35575516
PMCPMC13382517
OpenAlexW4225329213

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.