ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2022
High population burden of Omicron variant (B.1.1.529) is associated with the emergence of severe hepatitis of unknown etiology in children.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Characterization of a Hepatitis Outbreak in Children, 2021 to 2022.JAMA network open · 2022Pooled it
- Article
- Increased incidence of seronegative autoimmune hepatitis in children during SARS-CoV-2 pandemia period.Frontiers in immunology · 2024Observational
- Current knowledge about the outbreak of acute severe hepatitis of unknown origin among children.Journal of clinical and translational research · 2022Review
- Immunological characteristics of severe acute hepatitis of unknown origin in a child post SARS-CoV-2 infection.Clinical immunology (Orlando, Fla.) · 2022Article
- Severe Acute Hepatitis of Unknown Origin in Children: What Do We Know Today?Journal of clinical and translational hepatology · 2022Review
- Diagnosis, treatment, and prevention of severe acute hepatitis of unknown etiology in children.World journal of pediatrics : WJP · 2022Review
- Characteristics and implications of Omicron variant associated digestive system infections - Correspondence.International journal of surgery (London, England) · 2022Article
- Acute hepatitis of unknown origin in children: A combination of factors.Frontiers in pharmacology · 2022Review
- Potential protective benefits of Schisandrin B against severe acute hepatitis in children during the COVID-19 pandemic based on a network pharmacology analysis.Frontiers in pharmacology · 2022Article
- Hepatic dysfunctions in COVID-19 patients infected by the omicron variant of SARS-CoV-2.Frontiers in public health · 2022Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesTo explore a potential country-based ecological link between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant (B.1.1.529) infection and an apparent current global outbreak of severe hepatitis of unknown etiology among children.
methodsWe examined country-level statistical associations between reported detection of one or more unexplained severe hepatitis cases in children and the cumulative number of Omicron (B.1.1.529) cases in 38 Organisation for Economic Co-operation and Development (OECD) member countries plus Romania.
resultsAt least one focal hepatitis case was detected in 12 of the 39 countries included in our analysis. Numbers of confirmed Omicron cases reported in these 12 countries ranged from 4.4 to 11.9 million. Among the remaining 27 countries, this measure ranged from 0.5 to 5.5 million cases. Countries which reported focal hepatitis cases experienced higher precedent population burdens of Omicron cases relative to those which did not report any such hepatitis cases (p=0.013).
conclusionPrior exposure to Omicron variant (B.1.1.529) may be associated with an increased risk for severe hepatitis among children, indicating a critical need to conduct cofactor studies.
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